Antibodies in human serum that precipitate ribonuclease P

H. A. Gold, J. Craft, J. A. Hardin, M. Bartkiewicz, S. Altman

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Sera from certain patients with systemic lupus erythematosus (SLE) and related rheumatic diseases contain antibodies that selectively deplete extracts of HeLa cells of RNase P activity. Most of the sera that recognize RNase P, an endoribonuclease with an essential RNA subunit, also contain antibodies against another small ribonucleoprotein known as the Th antigen. A species of RNA about 400 nucleotides in length is the only RNA species found in common in all immunoprecipitates prepared with anti-RNase P antibodies. The discovery of antibodies against RNase P defines a major class of antibodies produced by patients with autoimmune disease.

Original languageEnglish (US)
Pages (from-to)5483-5487
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number15
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

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