Angiogenesis in P- and E-selectin-deficient mice

D. W. Hartwell; C. E. Butterfield; P. S. Frenette; B. M. Kenyon; R. O. Hynes; J. Folkman; Denisa D. Wagner

doi:10.1038/sj.mn.7300010

Angiogenesis in P- and E-selectin-deficient mice

D. W. Hartwell, C. E. Butterfield, P. S. Frenette, B. M. Kenyon, R. O. Hynes, J. Folkman, Denisa D. Wagner

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might he involved in angiogenesis however, mice deficient in the endothelial selectins develop normally. To clarify the role of enclothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Microcirculation
Volume	5
Issue number	2-3
DOIs	https://doi.org/10.1038/sj.mn.7300010
State	Published - 1998
Externally published	Yes

Keywords

Angiogenesis
Selectins
TNFα
bFGF

ASJC Scopus subject areas

Physiology
Molecular Biology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1038/sj.mn.7300010

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title = "Angiogenesis in P- and E-selectin-deficient mice",

abstract = "Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might he involved in angiogenesis however, mice deficient in the endothelial selectins develop normally. To clarify the role of enclothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.",

keywords = "Angiogenesis, Selectins, TNFα, bFGF",

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doi = "10.1038/sj.mn.7300010",

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}

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T1 - Angiogenesis in P- and E-selectin-deficient mice

AU - Hartwell, D. W.

AU - Butterfield, C. E.

AU - Frenette, P. S.

AU - Kenyon, B. M.

AU - Hynes, R. O.

AU - Folkman, J.

AU - Wagner, Denisa D.

PY - 1998

Y1 - 1998

N2 - Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might he involved in angiogenesis however, mice deficient in the endothelial selectins develop normally. To clarify the role of enclothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.

AB - Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might he involved in angiogenesis however, mice deficient in the endothelial selectins develop normally. To clarify the role of enclothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.

KW - Angiogenesis

KW - Selectins

KW - TNFα

KW - bFGF

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Angiogenesis in P- and E-selectin-deficient mice

Abstract

Keywords

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