Angiogenesis in P- and E-selectin-deficient mice

D. W. Hartwell, C. E. Butterfield, P. S. Frenette, B. M. Kenyon, R. O. Hynes, J. Folkman, Denisa D. Wagner

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might he involved in angiogenesis however, mice deficient in the endothelial selectins develop normally. To clarify the role of enclothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalMicrocirculation
Volume5
Issue number2-3
DOIs
StatePublished - 1998

Keywords

  • Angiogenesis
  • Selectins
  • TNFα
  • bFGF

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Hartwell, D. W., Butterfield, C. E., Frenette, P. S., Kenyon, B. M., Hynes, R. O., Folkman, J., & Wagner, D. D. (1998). Angiogenesis in P- and E-selectin-deficient mice. Microcirculation, 5(2-3), 173-178. https://doi.org/10.1038/sj.mn.7300010