Analysis of GNAZ gene polymorphism in bipolar affective disorder

Takuya Saito, Demitri F. Papolos, Danielle Chernak, Mark H. Rapaport, John R. Kelsoe, Herbert M. Lachman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein α subunit gene Gαz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number4
DOIs
StatePublished - Aug 20 1999

Keywords

  • Bipolar disorder
  • Chromosome 22
  • G-protein
  • Manic depression
  • Manic depressive illness

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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