Analysis of GNAZ gene polymorphism in bipolar affective disorder

Takuya Saito; Demitri F. Papolos; Danielle Chernak; Mark H. Rapaport; John R. Kelsoe; Herbert M. Lachman

doi:10.1002/(SICI)1096-8628(19990820)88:4<324::AID-AJMG7>3.0.CO;2-M

Analysis of GNAZ gene polymorphism in bipolar affective disorder

Takuya Saito, Demitri F. Papolos, Danielle Chernak, Mark H. Rapaport, John R. Kelsoe, Herbert M. Lachman

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein α subunit gene Gαz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.

Original language	English (US)
Pages (from-to)	324-328
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	88
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19990820)88:4<324::AID-AJMG7>3.0.CO;2-M
State	Published - Aug 20 1999

Keywords

Bipolar disorder
Chromosome 22
G-protein
Manic depression
Manic depressive illness

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1096-8628(19990820)88:4<324::AID-AJMG7>3.0.CO;2-M

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title = "Analysis of GNAZ gene polymorphism in bipolar affective disorder",

abstract = "Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein α subunit gene Gαz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.",

keywords = "Bipolar disorder, Chromosome 22, G-protein, Manic depression, Manic depressive illness",

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year = "1999",

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AU - Saito, Takuya

AU - Papolos, Demitri F.

AU - Chernak, Danielle

AU - Rapaport, Mark H.

AU - Kelsoe, John R.

AU - Lachman, Herbert M.

PY - 1999/8/20

Y1 - 1999/8/20

N2 - Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein α subunit gene Gαz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.

AB - Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein α subunit gene Gαz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.

KW - Bipolar disorder

KW - Chromosome 22

KW - G-protein

KW - Manic depression

KW - Manic depressive illness

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Analysis of GNAZ gene polymorphism in bipolar affective disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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