Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Mark J. Russ; Herbert M. Lachman; Todd Kashdan; Takuya Saito; Senada Bajmakovic-Kacila

doi:10.1016/S0165-1781(00)00128-1

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Mark J. Russ, Herbert M. Lachman, Todd Kashdan, Takuya Saito, Senada Bajmakovic-Kacila

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	Psychiatry Research
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(00)00128-1
State	Published - Feb 14 2000

Keywords

Hopelessness
Major depression
Serotonin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0165-1781(00)00128-1

Cite this

@article{f97a4c10d91f418b81d9faa31a1d9fe9,

title = "Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide",

abstract = "Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Hopelessness, Major depression, Serotonin",

author = "Russ, {Mark J.} and Lachman, {Herbert M.} and Todd Kashdan and Takuya Saito and Senada Bajmakovic-Kacila",

year = "2000",

month = feb,

day = "14",

doi = "10.1016/S0165-1781(00)00128-1",

language = "English (US)",

volume = "93",

pages = "73--78",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

AU - Russ, Mark J.

AU - Lachman, Herbert M.

AU - Kashdan, Todd

AU - Saito, Takuya

AU - Bajmakovic-Kacila, Senada

PY - 2000/2/14

Y1 - 2000/2/14

N2 - Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

AB - Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

KW - Hopelessness

KW - Major depression

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0034056199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034056199&partnerID=8YFLogxK

U2 - 10.1016/S0165-1781(00)00128-1

DO - 10.1016/S0165-1781(00)00128-1

M3 - Article

C2 - 10699230

AN - SCOPUS:0034056199

SN - 0165-1781

VL - 93

SP - 73

EP - 78

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this