Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Mark J. Russ, Herbert M. Lachman, Todd Kashdan, Takuya Saito, Senada Bajmakovic-Kacila

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalPsychiatry Research
Volume93
Issue number1
DOIs
StatePublished - Feb 14 2000

Keywords

  • Hopelessness
  • Major depression
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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