Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Feb 14 2000|
- Major depression
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry