Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-associated personality traits

M. V. Alfimova, M. V. Monakhov, V. E. Golimbet, G. I. Korovaitseva, G. L. Lyashenko

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neurotism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

Original languageEnglish (US)
Pages (from-to)434-436
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume149
Issue number4
DOIs
Publication statusPublished - Oct 1 2010
Externally publishedYes

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Keywords

  • gene
  • health
  • personality
  • serotonin
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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