Analogs of Camptothecin

James A. Bristol, Daniel L. Comins, Richard W. Davenport, Michael J. Kane, Robert E. Lyle, John R. Maloney, David E. Portlock, Susan Band Horwitz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hvdroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells. Each of these analogs had decreased activity as compared with camptothecin and there was no degradation oi DNA in the HeLa cells. This suggests that the D and E rings are not a sufficient requirement for camptothecin-like activity.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalJournal of Medicinal Chemistry
Volume18
Issue number5
DOIs
StatePublished - May 1 1975

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Camptothecin
HeLa Cells
Lymphoid Leukemia
DNA
RNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Bristol, J. A., Comins, D. L., Davenport, R. W., Kane, M. J., Lyle, R. E., Maloney, J. R., ... Band Horwitz, S. (1975). Analogs of Camptothecin. Journal of Medicinal Chemistry, 18(5), 535-537. https://doi.org/10.1021/jm00239a024

Analogs of Camptothecin. / Bristol, James A.; Comins, Daniel L.; Davenport, Richard W.; Kane, Michael J.; Lyle, Robert E.; Maloney, John R.; Portlock, David E.; Band Horwitz, Susan.

In: Journal of Medicinal Chemistry, Vol. 18, No. 5, 01.05.1975, p. 535-537.

Research output: Contribution to journalArticle

Bristol, JA, Comins, DL, Davenport, RW, Kane, MJ, Lyle, RE, Maloney, JR, Portlock, DE & Band Horwitz, S 1975, 'Analogs of Camptothecin', Journal of Medicinal Chemistry, vol. 18, no. 5, pp. 535-537. https://doi.org/10.1021/jm00239a024
Bristol JA, Comins DL, Davenport RW, Kane MJ, Lyle RE, Maloney JR et al. Analogs of Camptothecin. Journal of Medicinal Chemistry. 1975 May 1;18(5):535-537. https://doi.org/10.1021/jm00239a024
Bristol, James A. ; Comins, Daniel L. ; Davenport, Richard W. ; Kane, Michael J. ; Lyle, Robert E. ; Maloney, John R. ; Portlock, David E. ; Band Horwitz, Susan. / Analogs of Camptothecin. In: Journal of Medicinal Chemistry. 1975 ; Vol. 18, No. 5. pp. 535-537.
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