Analogs of Camptothecin

James A. Bristol, Daniel L. Comins, Richard W. Davenport, Michael J. Kane, Robert E. Lyle, John R. Maloney, David E. Portlock, Susan B. Horwitz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hvdroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells. Each of these analogs had decreased activity as compared with camptothecin and there was no degradation oi DNA in the HeLa cells. This suggests that the D and E rings are not a sufficient requirement for camptothecin-like activity.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalJournal of Medicinal Chemistry
Volume18
Issue number5
DOIs
StatePublished - May 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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