@article{bd946d2b36fc49fa90d0ef58f5d8f73c,
title = "An innate antiviral pathway acting before interferons at epithelial surfaces",
abstract = "Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.",
author = "Iversen, {Marie B.} and Reinert, {Line S.} and Thomsen, {Martin K.} and Ieva Bagdonaite and Ramya Nandakumar and Natalia Cheshenko and Thaneas Prabakaran and Vakhrushev, {Sergey Y.} and Malgosha Krzyzowska and Kratholm, {Sine K.} and Fernando Ruiz-Perez and Petersen, {Steen V.} and Stanislas Goriely and Bibby, {Bo Martin} and Kristina Eriksson and J{\"u}rgen Ruland and Thomsen, {Allan R.} and Herold, {Betsy C.} and Wandall, {Hans H.} and Sebastian Frische and Holm, {Christian K.} and Paludan, {S{\o}ren R.}",
note = "Funding Information: We thank K.S. Petersen and I.M. Poulsen for technical assistance and the AU FACS Core facility for technical help. Supported by The Danish Medical Research Council (12-124330 to S.R.P.; 1331-00133B to H.H.W.), the Novo Nordisk Foundation (S.R.P.), the Lundbeck Foundation (R34-3855 to S.R.P.), Aarhus University Research Foundation (S.R.P.), the EU FP7 Mobilex program (1333-00090A to M.K.T.), the US National Institutes of Health (AI065309 to B.C.H.), Faculty of Health Sciences, AU (M.B.I.), the Danish National Research Foundation (DNRF107 to H.H.W.), the Excellence Programme for Interdisciplinary Research (CDO2016 to H.H.W.), the German Research Foundation (DFG, SFB 1054 to J.R.) and the European Research Council (FP7, grant agreement 322865 to J.R.).",
year = "2016",
month = feb,
day = "1",
doi = "10.1038/ni.3319",
language = "English (US)",
volume = "17",
pages = "150--158",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "2",
}