An Ethical Exploration of Barriers to Research on Controlled Drugs

Michael H. Andreae, Evelyn Rhodes, Tyler Bourgoise, George M. Carter, Robert S. White, Debbie Indyk, Henry Sacks, Rosamond Rhodes

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We examine the ethical, social, and regulatory barriers that may hinder research on therapeutic potential of certain controversial controlled substances like marijuana, heroin, or ketamine. Hazards for individuals and society and potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of these substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may, however, limit research on their considerable therapeutic potential. We review the surprisingly sparse literature and address the particular ethical concerns pertinent to research with illicit and addictive substances, such as undue inducement, informed consent, therapeutic misconception, and risk to participants, researchers, and institutions. We consider the perspectives of key research stakeholders and explore whether they may be infected with bias. We conclude by proposing an empirical research agenda to provide an evidentiary basis for ethical reasoning.

Original languageEnglish (US)
Pages (from-to)36-47
Number of pages12
JournalAmerican Journal of Bioethics
Volume16
Issue number4
DOIs
StatePublished - Apr 2 2016

Keywords

  • biomedical research
  • confidentiality and privacy
  • human subjects research
  • informed consent
  • institutional review board
  • research ethics

ASJC Scopus subject areas

  • Health Policy
  • Issues, ethics and legal aspects

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    Andreae, M. H., Rhodes, E., Bourgoise, T., Carter, G. M., White, R. S., Indyk, D., Sacks, H., & Rhodes, R. (2016). An Ethical Exploration of Barriers to Research on Controlled Drugs. American Journal of Bioethics, 16(4), 36-47. https://doi.org/10.1080/15265161.2016.1145282