Abstract
Using a new procedure that combines electron-density correlation with biochemical information, we have fitted the crystal structure of the N- terminal actin-binding domain of human T-fimbrin to helical reconstructions of fimbrin-decorated actin filaments. The map locates the N-terminal calcium- binding domain and identifies actin-binding site residues on the two calponin-homology domains of fimbrin. Based on this map, we propose a model of a fimbrin crosslink in an actin bundle and its regulation by calcium.
Original language | English (US) |
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Pages (from-to) | 787-792 |
Number of pages | 6 |
Journal | Nature structural biology |
Volume | 5 |
Issue number | 9 |
DOIs | |
State | Published - Sep 9 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics