An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses

Gustavo Helguera, Stephanie Jemielity, Jonathan Abraham, Sandra M. Cordo, M. Guadalupe Martinez, José A. Rodríguez, Carlos Bregni, Jinyize J. Wang, Michael Farzan, Manuel L. Penichet, Nélida A. Candurra, Hyeryun Choe

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers.

Original languageEnglish (US)
Pages (from-to)4024-4028
Number of pages5
JournalJournal of virology
Volume86
Issue number7
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Helguera, G., Jemielity, S., Abraham, J., Cordo, S. M., Martinez, M. G., Rodríguez, J. A., Bregni, C., Wang, J. J., Farzan, M., Penichet, M. L., Candurra, N. A., & Choe, H. (2012). An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses. Journal of virology, 86(7), 4024-4028. https://doi.org/10.1128/JVI.06397-11