An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

Nicole Schreiber-Agus, Lynda Chin, Ken Chen, Richard Torres, Govinda Rao, Peter Guida, Arthur I. Skoultchi, Ronald A. DePinho

Research output: Contribution to journalArticle

316 Scopus citations

Abstract

Documented interactions among members of the Myc superfamily support a yin-yang model for the regulation of Myc-responsive genes in which transactivation-competent Myc-Max heterodimers are opposed by repressive Mxi1-Max or Mad-Max complexes. Analysis of mouse mxi1 has led to the identification of two mxi1 transcript forms possessing open reading frames that differ in their capacity to encode a short amino-terminal α-helical domain. The presence of this segment dramatically augments the suppressive potential of Mxil and allows for association with a mammalian protein that is structurally homologous to the yeast transcriptional repressor SIN3. These findings provide a mechanistic basis for the antagonistic actions of Mxi1 on Myc activity that appears to be mediated in part through the recruitment of a putative transcriptional repressor.

Original languageEnglish (US)
Pages (from-to)777-786
Number of pages10
JournalCell
Volume80
Issue number5
DOIs
StatePublished - Mar 10 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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