Amyloidogenesis is neither accelerated nor enhanced by injections of preformed fibrils in mice transgenic for wild-type human transthyretin: The question of infectivity

Clement E. Tagoe, David French, Gloria Gallo, Joel N. Buxbaum

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

It is possible to accelerate amyloid formation in both the Senescence Accelerated Mouse, where ApoAIIC is the precursor, and in murine Amyloid A (AA) by the injection of preformed fibrils in the former and amyloid enhancing factor, which appears to consist of AA fibril fragments, in the latter. These two observations have raised the question of whether murine amyloids, like scrapie, are infectious. Injection of preformed fibrils into mice transgenic for many copies of the human wild-type transthyretin gene do not result in acceleration or enhancement of the process of deposition or the conversion of non-Congophilic deposits to fibrils.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalAmyloid
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

Keywords

  • Amyloidogenesis
  • Seeding
  • Transgenic animals
  • Transthyretin

ASJC Scopus subject areas

  • Internal Medicine

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