Amphetamine and maternal behavior: Dose response relationships

M. Piccirillo, Jonathan E. Alpert, D. J. Cohen, B. A. Shaywitz

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval, retrieval latency, inter-retrieval interval, number of pup retrieved and number of corners to which they were retrieved, time nest building, number of paper strips used, nursing time, time in motion, and number of squares entered. Disruption was dose-dependent for all the preceding except number of corners and time nest building. Amphetamine had no effect on the rate of maternal locomotion. The impact of amphetamine on nursing was significantly greater at pup ages of 3-4 days than at 10-11 days. Drug-induced augmentation of arousal exceeding optimal levels for adequate care-giving and locomotor stimulation incompatible with elements of maternal behavior may account for dose-dependent impairment in the range of 0.25 to 1.50 mg/kg d-amphetamine.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalPsychopharmacology
Volume70
Issue number2
DOIs
StatePublished - Oct 1980
Externally publishedYes

Fingerprint

Maternal Behavior
Amphetamine
Dextroamphetamine
Nursing
Drug Synergism
Mothers
Locomotion
Arousal
Body Weight

Keywords

  • Arousal
  • d-Amphetamine
  • Dose dependence
  • Maternal behavior
  • Pup maturation
  • Rat behavior
  • Rate dependence

ASJC Scopus subject areas

  • Pharmacology

Cite this

Amphetamine and maternal behavior : Dose response relationships. / Piccirillo, M.; Alpert, Jonathan E.; Cohen, D. J.; Shaywitz, B. A.

In: Psychopharmacology, Vol. 70, No. 2, 10.1980, p. 195-199.

Research output: Contribution to journalArticle

Piccirillo, M. ; Alpert, Jonathan E. ; Cohen, D. J. ; Shaywitz, B. A. / Amphetamine and maternal behavior : Dose response relationships. In: Psychopharmacology. 1980 ; Vol. 70, No. 2. pp. 195-199.
@article{e29cfc9d6e8a47b2a32ea057ce779628,
title = "Amphetamine and maternal behavior: Dose response relationships",
abstract = "Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval, retrieval latency, inter-retrieval interval, number of pup retrieved and number of corners to which they were retrieved, time nest building, number of paper strips used, nursing time, time in motion, and number of squares entered. Disruption was dose-dependent for all the preceding except number of corners and time nest building. Amphetamine had no effect on the rate of maternal locomotion. The impact of amphetamine on nursing was significantly greater at pup ages of 3-4 days than at 10-11 days. Drug-induced augmentation of arousal exceeding optimal levels for adequate care-giving and locomotor stimulation incompatible with elements of maternal behavior may account for dose-dependent impairment in the range of 0.25 to 1.50 mg/kg d-amphetamine.",
keywords = "Arousal, d-Amphetamine, Dose dependence, Maternal behavior, Pup maturation, Rat behavior, Rate dependence",
author = "M. Piccirillo and Alpert, {Jonathan E.} and Cohen, {D. J.} and Shaywitz, {B. A.}",
year = "1980",
month = "10",
doi = "10.1007/BF00435314",
language = "English (US)",
volume = "70",
pages = "195--199",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Amphetamine and maternal behavior

T2 - Dose response relationships

AU - Piccirillo, M.

AU - Alpert, Jonathan E.

AU - Cohen, D. J.

AU - Shaywitz, B. A.

PY - 1980/10

Y1 - 1980/10

N2 - Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval, retrieval latency, inter-retrieval interval, number of pup retrieved and number of corners to which they were retrieved, time nest building, number of paper strips used, nursing time, time in motion, and number of squares entered. Disruption was dose-dependent for all the preceding except number of corners and time nest building. Amphetamine had no effect on the rate of maternal locomotion. The impact of amphetamine on nursing was significantly greater at pup ages of 3-4 days than at 10-11 days. Drug-induced augmentation of arousal exceeding optimal levels for adequate care-giving and locomotor stimulation incompatible with elements of maternal behavior may account for dose-dependent impairment in the range of 0.25 to 1.50 mg/kg d-amphetamine.

AB - Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval, retrieval latency, inter-retrieval interval, number of pup retrieved and number of corners to which they were retrieved, time nest building, number of paper strips used, nursing time, time in motion, and number of squares entered. Disruption was dose-dependent for all the preceding except number of corners and time nest building. Amphetamine had no effect on the rate of maternal locomotion. The impact of amphetamine on nursing was significantly greater at pup ages of 3-4 days than at 10-11 days. Drug-induced augmentation of arousal exceeding optimal levels for adequate care-giving and locomotor stimulation incompatible with elements of maternal behavior may account for dose-dependent impairment in the range of 0.25 to 1.50 mg/kg d-amphetamine.

KW - Arousal

KW - d-Amphetamine

KW - Dose dependence

KW - Maternal behavior

KW - Pup maturation

KW - Rat behavior

KW - Rate dependence

UR - http://www.scopus.com/inward/record.url?scp=0018949981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018949981&partnerID=8YFLogxK

U2 - 10.1007/BF00435314

DO - 10.1007/BF00435314

M3 - Article

C2 - 6776580

AN - SCOPUS:0018949981

VL - 70

SP - 195

EP - 199

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -