Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions

Joseph D. Schulman, Leon I. Mann, Larry Doores, Sybil Duchin, John Halverstam, John Mastrantonio

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Serum amino acid concentrations were quantitated using gas-liquid chromatography on blood samples drawn from fetal carotid artery, fetal sagittal vein, and a maternal peripheral artery under baseline conditions and during maternal and fetal hypoglycemia induced acutely by maternal insulin infusion. Serum concentrations of all amino acids were higher in the fetus than in the mother; in most cases, the letal levels were 2–4 times higher than the maternal. A similar pattern was observed during hypoglycemia, although there was a tendency for most maternal arterial serum amino acid concentrations to decline during hypoglycemia and for most fetal sagittal vein concentrations to increase. Positive arterio venous differences in amino acid concentration across the fetal brain were demonstrated for 14 of 15 amino acids. These differences decreased during hypoglycemia for 12 of these 14 amino acids, and for 7 of these amino acids the hypoglycemic arteriovenous differences actually became negative. The data suggest that acute fetomaternal hypoglycemia impairs net uptake of multiple amino acids by the fetal brain. The relationship, if any, between such impairment and the untoward clinical effects of severe perinatal and/or neonatal hypoglycemia must be established by further investigation.

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalNeonatology
Volume25
Issue number1-2
DOIs
StatePublished - 1974
Externally publishedYes

Fingerprint

Hypoglycemic Agents
Hypoglycemia
Amino Acids
Brain
Mothers
Veins
Serum
Carotid Arteries
Gas Chromatography
Fetus
Arteries
Insulin

Keywords

  • Amino acids
  • Brain metabolism
  • Hypoglycemia
  • Placental gradient

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Schulman, J. D., Mann, L. I., Doores, L., Duchin, S., Halverstam, J., & Mastrantonio, J. (1974). Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions. Neonatology, 25(1-2), 57-65. https://doi.org/10.1159/000240679

Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions. / Schulman, Joseph D.; Mann, Leon I.; Doores, Larry; Duchin, Sybil; Halverstam, John; Mastrantonio, John.

In: Neonatology, Vol. 25, No. 1-2, 1974, p. 57-65.

Research output: Contribution to journalArticle

Schulman, JD, Mann, LI, Doores, L, Duchin, S, Halverstam, J & Mastrantonio, J 1974, 'Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions', Neonatology, vol. 25, no. 1-2, pp. 57-65. https://doi.org/10.1159/000240679
Schulman JD, Mann LI, Doores L, Duchin S, Halverstam J, Mastrantonio J. Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions. Neonatology. 1974;25(1-2):57-65. https://doi.org/10.1159/000240679
Schulman, Joseph D. ; Mann, Leon I. ; Doores, Larry ; Duchin, Sybil ; Halverstam, John ; Mastrantonio, John. / Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions. In: Neonatology. 1974 ; Vol. 25, No. 1-2. pp. 57-65.
@article{51839dc2124b43ecb37778ff136d7dde,
title = "Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions",
abstract = "Serum amino acid concentrations were quantitated using gas-liquid chromatography on blood samples drawn from fetal carotid artery, fetal sagittal vein, and a maternal peripheral artery under baseline conditions and during maternal and fetal hypoglycemia induced acutely by maternal insulin infusion. Serum concentrations of all amino acids were higher in the fetus than in the mother; in most cases, the letal levels were 2–4 times higher than the maternal. A similar pattern was observed during hypoglycemia, although there was a tendency for most maternal arterial serum amino acid concentrations to decline during hypoglycemia and for most fetal sagittal vein concentrations to increase. Positive arterio venous differences in amino acid concentration across the fetal brain were demonstrated for 14 of 15 amino acids. These differences decreased during hypoglycemia for 12 of these 14 amino acids, and for 7 of these amino acids the hypoglycemic arteriovenous differences actually became negative. The data suggest that acute fetomaternal hypoglycemia impairs net uptake of multiple amino acids by the fetal brain. The relationship, if any, between such impairment and the untoward clinical effects of severe perinatal and/or neonatal hypoglycemia must be established by further investigation.",
keywords = "Amino acids, Brain metabolism, Hypoglycemia, Placental gradient",
author = "Schulman, {Joseph D.} and Mann, {Leon I.} and Larry Doores and Sybil Duchin and John Halverstam and John Mastrantonio",
year = "1974",
doi = "10.1159/000240679",
language = "English (US)",
volume = "25",
pages = "57--65",
journal = "Neonatology",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "1-2",

}

TY - JOUR

T1 - Amino acid metabolism by the fetal brain during normal and hypoglycemic conditions

AU - Schulman, Joseph D.

AU - Mann, Leon I.

AU - Doores, Larry

AU - Duchin, Sybil

AU - Halverstam, John

AU - Mastrantonio, John

PY - 1974

Y1 - 1974

N2 - Serum amino acid concentrations were quantitated using gas-liquid chromatography on blood samples drawn from fetal carotid artery, fetal sagittal vein, and a maternal peripheral artery under baseline conditions and during maternal and fetal hypoglycemia induced acutely by maternal insulin infusion. Serum concentrations of all amino acids were higher in the fetus than in the mother; in most cases, the letal levels were 2–4 times higher than the maternal. A similar pattern was observed during hypoglycemia, although there was a tendency for most maternal arterial serum amino acid concentrations to decline during hypoglycemia and for most fetal sagittal vein concentrations to increase. Positive arterio venous differences in amino acid concentration across the fetal brain were demonstrated for 14 of 15 amino acids. These differences decreased during hypoglycemia for 12 of these 14 amino acids, and for 7 of these amino acids the hypoglycemic arteriovenous differences actually became negative. The data suggest that acute fetomaternal hypoglycemia impairs net uptake of multiple amino acids by the fetal brain. The relationship, if any, between such impairment and the untoward clinical effects of severe perinatal and/or neonatal hypoglycemia must be established by further investigation.

AB - Serum amino acid concentrations were quantitated using gas-liquid chromatography on blood samples drawn from fetal carotid artery, fetal sagittal vein, and a maternal peripheral artery under baseline conditions and during maternal and fetal hypoglycemia induced acutely by maternal insulin infusion. Serum concentrations of all amino acids were higher in the fetus than in the mother; in most cases, the letal levels were 2–4 times higher than the maternal. A similar pattern was observed during hypoglycemia, although there was a tendency for most maternal arterial serum amino acid concentrations to decline during hypoglycemia and for most fetal sagittal vein concentrations to increase. Positive arterio venous differences in amino acid concentration across the fetal brain were demonstrated for 14 of 15 amino acids. These differences decreased during hypoglycemia for 12 of these 14 amino acids, and for 7 of these amino acids the hypoglycemic arteriovenous differences actually became negative. The data suggest that acute fetomaternal hypoglycemia impairs net uptake of multiple amino acids by the fetal brain. The relationship, if any, between such impairment and the untoward clinical effects of severe perinatal and/or neonatal hypoglycemia must be established by further investigation.

KW - Amino acids

KW - Brain metabolism

KW - Hypoglycemia

KW - Placental gradient

UR - http://www.scopus.com/inward/record.url?scp=0016294606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016294606&partnerID=8YFLogxK

U2 - 10.1159/000240679

DO - 10.1159/000240679

M3 - Article

C2 - 4472974

AN - SCOPUS:0016294606

VL - 25

SP - 57

EP - 65

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 1-2

ER -