Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients

Arthur R. Garan, Nir Uriel, Gabriel Sayer, Daniel Sims, Doris Zahner, Maryjane Farr, Donna Mancini, Ulrich P. Jorde

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Keywords

  • heart transplantation
  • hemodynamics
  • rejection
  • systemic vascular resistance

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Fingerprint Dive into the research topics of 'Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients'. Together they form a unique fingerprint.

  • Cite this