TY - JOUR
T1 - Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
AU - Chamian, Francesca
AU - Lin, Shao Lee
AU - Lee, Edmund
AU - Kikuchi, Toyoko
AU - Gilleaudeau, Patricia
AU - Sullivan-Whalen, Mary
AU - Cardinale, Irma
AU - Khatcherian, Artemis
AU - Novitskaya, Inna
AU - Wittkowski, Knut M.
AU - Krueger, James G.
AU - Lowes, Michelle A.
PY - 2007/6/7
Y1 - 2007/6/7
N2 - Background: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. Methods: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. Results: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63% reduction) for both CD4+ and CD8+ Tem, while central memory T cells (Tcm) (CCR7+CD45RA-) were less affected, and naïve T cells (CCR7+CD45RA-) were relatively spared. Circulating CD8+ effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. Conclusion: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
AB - Background: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. Methods: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. Results: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63% reduction) for both CD4+ and CD8+ Tem, while central memory T cells (Tcm) (CCR7+CD45RA-) were less affected, and naïve T cells (CCR7+CD45RA-) were relatively spared. Circulating CD8+ effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. Conclusion: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
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U2 - 10.1186/1479-5876-5-27
DO - 10.1186/1479-5876-5-27
M3 - Article
C2 - 17555598
AN - SCOPUS:34447329553
SN - 1479-5876
VL - 5
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
M1 - 27
ER -