Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

Francesca Chamian, Shao Lee Lin, Edmund Lee, Toyoko Kikuchi, Patricia Gilleaudeau, Mary Sullivan-Whalen, Irma Cardinale, Artemis Khatcherian, Inna Novitskaya, Knut M. Wittkowski, James G. Krueger, Michelle A. Lowes

Research output: Contribution to journalArticle

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Abstract

Background: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. Methods: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. Results: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63% reduction) for both CD4+ and CD8+ Tem, while central memory T cells (Tcm) (CCR7+CD45RA-) were less affected, and naïve T cells (CCR7+CD45RA-) were relatively spared. Circulating CD8+ effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. Conclusion: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.

Original languageEnglish (US)
Article number27
JournalJournal of Translational Medicine
Volume5
DOIs
StatePublished - Jun 7 2007
Externally publishedYes

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T-cells
Psoriasis
T-Lymphocytes
Data storage equipment
Patient treatment
Biological Therapy
alefacept
Autoimmune Diseases
Leukocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. / Chamian, Francesca; Lin, Shao Lee; Lee, Edmund; Kikuchi, Toyoko; Gilleaudeau, Patricia; Sullivan-Whalen, Mary; Cardinale, Irma; Khatcherian, Artemis; Novitskaya, Inna; Wittkowski, Knut M.; Krueger, James G.; Lowes, Michelle A.

In: Journal of Translational Medicine, Vol. 5, 27, 07.06.2007.

Research output: Contribution to journalArticle

Chamian, F, Lin, SL, Lee, E, Kikuchi, T, Gilleaudeau, P, Sullivan-Whalen, M, Cardinale, I, Khatcherian, A, Novitskaya, I, Wittkowski, KM, Krueger, JG & Lowes, MA 2007, 'Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis', Journal of Translational Medicine, vol. 5, 27. https://doi.org/10.1186/1479-5876-5-27
Chamian, Francesca ; Lin, Shao Lee ; Lee, Edmund ; Kikuchi, Toyoko ; Gilleaudeau, Patricia ; Sullivan-Whalen, Mary ; Cardinale, Irma ; Khatcherian, Artemis ; Novitskaya, Inna ; Wittkowski, Knut M. ; Krueger, James G. ; Lowes, Michelle A. / Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. In: Journal of Translational Medicine. 2007 ; Vol. 5.
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abstract = "Background: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. Methods: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. Results: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63{\%} reduction) for both CD4+ and CD8+ Tem, while central memory T cells (Tcm) (CCR7+CD45RA-) were less affected, and na{\"i}ve T cells (CCR7+CD45RA-) were relatively spared. Circulating CD8+ effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. Conclusion: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.",
author = "Francesca Chamian and Lin, {Shao Lee} and Edmund Lee and Toyoko Kikuchi and Patricia Gilleaudeau and Mary Sullivan-Whalen and Irma Cardinale and Artemis Khatcherian and Inna Novitskaya and Wittkowski, {Knut M.} and Krueger, {James G.} and Lowes, {Michelle A.}",
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AU - Lin, Shao Lee

AU - Lee, Edmund

AU - Kikuchi, Toyoko

AU - Gilleaudeau, Patricia

AU - Sullivan-Whalen, Mary

AU - Cardinale, Irma

AU - Khatcherian, Artemis

AU - Novitskaya, Inna

AU - Wittkowski, Knut M.

AU - Krueger, James G.

AU - Lowes, Michelle A.

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