Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies

J. M. Genkinger, D. J. Hunter, D. Spiegelman, K. E. Anderson, J. E. Buring, J. L. Freudenheim, R. A. Goldbohm, L. Harnack, S. E. Hankinson, S. C. Larsson, M. Leitzmann, M. L. McCullough, J. Marshall, A. B. Miller, C. Rodriguez, Thomas E. Rohan, A. Schatzkin, L. J. Schouten, A. Wolk, S. M. ZhangS. A. Smith-Warner

Research output: Contribution to journalArticle

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Abstract

Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalBritish Journal of Cancer
Volume94
Issue number5
DOIs
StatePublished - Mar 13 2006

Fingerprint

Ovarian Neoplasms
Cohort Studies
Alcohols
Folic Acid
Confidence Intervals
Acetaldehyde
Hormone Replacement Therapy
Wine
Oral Contraceptives
Parity
Proportional Hazards Models
Alcohol Drinking
Case-Control Studies
Estrogens
Carcinogenesis
Body Mass Index
Smoking
Hormones
Prospective Studies
Food

Keywords

  • Alcohol
  • Ovarian cancer
  • Pooled analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Genkinger, J. M., Hunter, D. J., Spiegelman, D., Anderson, K. E., Buring, J. E., Freudenheim, J. L., ... Smith-Warner, S. A. (2006). Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies. British Journal of Cancer, 94(5), 757-762. https://doi.org/10.1038/sj.bjc.6603020

Alcohol intake and ovarian cancer risk : A pooled analysis of 10 cohort studies. / Genkinger, J. M.; Hunter, D. J.; Spiegelman, D.; Anderson, K. E.; Buring, J. E.; Freudenheim, J. L.; Goldbohm, R. A.; Harnack, L.; Hankinson, S. E.; Larsson, S. C.; Leitzmann, M.; McCullough, M. L.; Marshall, J.; Miller, A. B.; Rodriguez, C.; Rohan, Thomas E.; Schatzkin, A.; Schouten, L. J.; Wolk, A.; Zhang, S. M.; Smith-Warner, S. A.

In: British Journal of Cancer, Vol. 94, No. 5, 13.03.2006, p. 757-762.

Research output: Contribution to journalArticle

Genkinger, JM, Hunter, DJ, Spiegelman, D, Anderson, KE, Buring, JE, Freudenheim, JL, Goldbohm, RA, Harnack, L, Hankinson, SE, Larsson, SC, Leitzmann, M, McCullough, ML, Marshall, J, Miller, AB, Rodriguez, C, Rohan, TE, Schatzkin, A, Schouten, LJ, Wolk, A, Zhang, SM & Smith-Warner, SA 2006, 'Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies', British Journal of Cancer, vol. 94, no. 5, pp. 757-762. https://doi.org/10.1038/sj.bjc.6603020
Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Buring JE, Freudenheim JL et al. Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies. British Journal of Cancer. 2006 Mar 13;94(5):757-762. https://doi.org/10.1038/sj.bjc.6603020
Genkinger, J. M. ; Hunter, D. J. ; Spiegelman, D. ; Anderson, K. E. ; Buring, J. E. ; Freudenheim, J. L. ; Goldbohm, R. A. ; Harnack, L. ; Hankinson, S. E. ; Larsson, S. C. ; Leitzmann, M. ; McCullough, M. L. ; Marshall, J. ; Miller, A. B. ; Rodriguez, C. ; Rohan, Thomas E. ; Schatzkin, A. ; Schouten, L. J. ; Wolk, A. ; Zhang, S. M. ; Smith-Warner, S. A. / Alcohol intake and ovarian cancer risk : A pooled analysis of 10 cohort studies. In: British Journal of Cancer. 2006 ; Vol. 94, No. 5. pp. 757-762.
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