Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro

Oxana V. Denisova, Sandra Sod̈erholm, Salla Virtanen, Carina Von Schantz, Dmitrii Bychkov, Elena Vashchinkina, Jens Desloovere, Janne Tynell, Niina Ikonen, Linda L. Theisen, Tuula A. Nyman, Sampsa Matikainen, Olli Kallioniemi, Ilkka Julkunen, Claude P. Muller, Xavier Saelens, Vladislav V. Verkhusha, Denis E. Kainov

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that the Akt inhibitor MK2206 blocks influenza pH1N1 virus infection in vitro. In particular, at noncytotoxic concentrations, MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9, and H5N1 viruses, indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.

Original languageEnglish (US)
Pages (from-to)3689-3696
Number of pages8
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number7
DOIs
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Denisova, O. V., Sod̈erholm, S., Virtanen, S., Von Schantz, C., Bychkov, D., Vashchinkina, E., Desloovere, J., Tynell, J., Ikonen, N., Theisen, L. L., Nyman, T. A., Matikainen, S., Kallioniemi, O., Julkunen, I., Muller, C. P., Saelens, X., Verkhusha, V. V., & Kainov, D. E. (2014). Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrobial Agents and Chemotherapy, 58(7), 3689-3696. https://doi.org/10.1128/AAC.02798-13