Aging of the Genome: The dual role of DNA in life and death

Research output: Book/ReportBook

30 Scopus citations

Abstract

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides a synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Original languageEnglish (US)
PublisherOxford University Press
Number of pages384
ISBN (Electronic)9780191728242
ISBN (Print)9780198569237
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Keywords

  • Aging
  • Cause of aging
  • Complex organisms
  • DNA mutations
  • Genome
  • Genome functioning
  • Genomic instability
  • Somatic cells
  • Systems biology
  • Technology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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