Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

Richard M. Reznick, Haihong Zong, Ji Li, Katsutaro Morino, Irene K. Moore, Hannah J. Yu, Zhen Xiang Liu, Jianying Dong, Kirsty J. Mustard, Simon A. Hawley, Douglas Befroy, Marc Pypaert, D. Grahame Hardie, Lawrence H. Young, Gerald I. Shulman

Research output: Contribution to journalArticle

322 Scopus citations

Abstract

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-α2 activity by 5′-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with β-guanidinopropionic acid (β-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalCell metabolism
Volume5
Issue number2
DOIs
StatePublished - Feb 7 2007
Externally publishedYes

Keywords

  • HUMDISEASE

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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    Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z. X., Dong, J., Mustard, K. J., Hawley, S. A., Befroy, D., Pypaert, M., Hardie, D. G., Young, L. H., & Shulman, G. I. (2007). Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis. Cell metabolism, 5(2), 151-156. https://doi.org/10.1016/j.cmet.2007.01.008