Aging and genome maintenance

Lessons from the mouse?

Paul Hasty, Judith Campisi, Jan Hoeijmakers, Harry Van Steeg, Jan Vijg

Research output: Contribution to journalArticle

435 Citations (Scopus)

Abstract

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Original languageEnglish (US)
Pages (from-to)1355-1359
Number of pages5
JournalScience
Volume299
Issue number5611
DOIs
StatePublished - Feb 28 2003
Externally publishedYes

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Maintenance
Genome
Cell Survival
Yeasts

ASJC Scopus subject areas

  • General

Cite this

Hasty, P., Campisi, J., Hoeijmakers, J., Van Steeg, H., & Vijg, J. (2003). Aging and genome maintenance: Lessons from the mouse? Science, 299(5611), 1355-1359. https://doi.org/10.1126/science.1079161

Aging and genome maintenance : Lessons from the mouse? / Hasty, Paul; Campisi, Judith; Hoeijmakers, Jan; Van Steeg, Harry; Vijg, Jan.

In: Science, Vol. 299, No. 5611, 28.02.2003, p. 1355-1359.

Research output: Contribution to journalArticle

Hasty, P, Campisi, J, Hoeijmakers, J, Van Steeg, H & Vijg, J 2003, 'Aging and genome maintenance: Lessons from the mouse?', Science, vol. 299, no. 5611, pp. 1355-1359. https://doi.org/10.1126/science.1079161
Hasty P, Campisi J, Hoeijmakers J, Van Steeg H, Vijg J. Aging and genome maintenance: Lessons from the mouse? Science. 2003 Feb 28;299(5611):1355-1359. https://doi.org/10.1126/science.1079161
Hasty, Paul ; Campisi, Judith ; Hoeijmakers, Jan ; Van Steeg, Harry ; Vijg, Jan. / Aging and genome maintenance : Lessons from the mouse?. In: Science. 2003 ; Vol. 299, No. 5611. pp. 1355-1359.
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