Aging and genome maintenance: Lessons from the mouse?

Paul Hasty; Judith Campisi; Jan Hoeijmakers; Harry Van Steeg; Jan Vijg

doi:10.1126/science.1079161

Aging and genome maintenance: Lessons from the mouse?

Paul Hasty, Judith Campisi, Jan Hoeijmakers, Harry Van Steeg, Jan Vijg

Research output: Contribution to journal › Review article › peer-review

490 Scopus citations

Abstract

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Original language	English (US)
Pages (from-to)	1355-1359
Number of pages	5
Journal	Science
Volume	299
Issue number	5611
DOIs	https://doi.org/10.1126/science.1079161
State	Published - Feb 28 2003
Externally published	Yes

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AU - Van Steeg, Harry

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Aging and genome maintenance: Lessons from the mouse?

Abstract

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