Aging and genome maintenance: Lessons from the mouse?

Paul Hasty, Judith Campisi, Jan Hoeijmakers, Harry Van Steeg, Jan Vijg

Research output: Contribution to journalReview article

452 Scopus citations

Abstract

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Original languageEnglish (US)
Pages (from-to)1355-1359
Number of pages5
JournalScience
Volume299
Issue number5611
DOIs
StatePublished - Feb 28 2003
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Hasty, P., Campisi, J., Hoeijmakers, J., Van Steeg, H., & Vijg, J. (2003). Aging and genome maintenance: Lessons from the mouse? Science, 299(5611), 1355-1359. https://doi.org/10.1126/science.1079161