Abstract
Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness. This is caused by age-related changes of the immune system. Major immune defects at older age are lack of naïve T cells, impaired activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment (TME). Also innate immune responses are affected by aging, but this seems less abundant than adaptive immune responses. In this review we compared various cancer vaccine studies at young and old age, demonstrating the importance of both innate and adaptive immune responses for cancer immunotherapy. Moreover, we found suggestive evidence that innate immune responses could help improve adaptive immune responses through cancer vaccination in old age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 585-595 |
| Number of pages | 11 |
| Journal | Critical Reviews in Oncogenesis |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Adaptive immune responses
- Aging
- Cancer vaccination
- Innate immune responses
- Listeria monocytogenes
- T cell unresponsiveness
ASJC Scopus subject areas
- Cancer Research
Cite this
Aging and cancer vaccines. / Gravekamp, Claudia; Chandra, Dinesh.
In: Critical Reviews in Oncogenesis, Vol. 18, No. 6, 2013, p. 585-595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aging and cancer vaccines
AU - Gravekamp, Claudia
AU - Chandra, Dinesh
PY - 2013
Y1 - 2013
N2 - Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness. This is caused by age-related changes of the immune system. Major immune defects at older age are lack of naïve T cells, impaired activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment (TME). Also innate immune responses are affected by aging, but this seems less abundant than adaptive immune responses. In this review we compared various cancer vaccine studies at young and old age, demonstrating the importance of both innate and adaptive immune responses for cancer immunotherapy. Moreover, we found suggestive evidence that innate immune responses could help improve adaptive immune responses through cancer vaccination in old age.
AB - Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness. This is caused by age-related changes of the immune system. Major immune defects at older age are lack of naïve T cells, impaired activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment (TME). Also innate immune responses are affected by aging, but this seems less abundant than adaptive immune responses. In this review we compared various cancer vaccine studies at young and old age, demonstrating the importance of both innate and adaptive immune responses for cancer immunotherapy. Moreover, we found suggestive evidence that innate immune responses could help improve adaptive immune responses through cancer vaccination in old age.
KW - Adaptive immune responses
KW - Aging
KW - Cancer vaccination
KW - Innate immune responses
KW - Listeria monocytogenes
KW - T cell unresponsiveness
UR - http://www.scopus.com/inward/record.url?scp=84893068429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893068429&partnerID=8YFLogxK
U2 - 10.1615/CritRevOncog.2013010588
DO - 10.1615/CritRevOncog.2013010588
M3 - Article
C2 - 24579737
AN - SCOPUS:84893068429
VL - 18
SP - 585
EP - 595
JO - Critical Reviews in Oncogenesis
JF - Critical Reviews in Oncogenesis
SN - 0893-9675
IS - 6
ER -