Age‐Dependent Differences in the Anticonvulsant Effects of 2–Amino‐7‐Phosphono‐Heptanoic Acid or Ketamine Infusions Into the Substantia Nigra of Rats

John N.D. Wurpel, Ellen F. Sperber, Solomon L. Moshé

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Summary: Infusions of 2‐amino‐7‐phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16‐day‐old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalEpilepsia
Volume33
Issue number3
DOIs
StatePublished - May 1992

Keywords

  • 2‐Amino‐7‐phospho‐hepatanoic acid
  • Convulsions
  • Ketamine
  • Neurologic model
  • Substantia nigra

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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