@article{0b3a13329f384b3ea9b3622fc3e78273,
title = "Age-varying Associations of Depressive Symptoms and Heavy Episodic Drinking Throughout Adulthood Among People with HIV and Receiving care in Cameroon Within a National “treat all” Policy",
abstract = "Comorbid depression and heavy episodic drinking (HED) may threaten the success of “treat all” policies in sub-Saharan Africa as the population of people with HIV (PWH) ages. We investigated associations between depressive symptoms and heavy episodic drinking (HED) and the extent the relationship differed across ages among PWH receiving HIV care in Cameroon. We conducted a retrospective analysis of 18-60-year-old PWH on antiretroviral therapy in Cameroon from January 2016 to March 2020. Age-varying effect modelling was conducted to assess associations between depressive symptoms and HED across ages and by gender. Prevalence of depression and HED was highest at ages 20 and 25, respectively. After age 25, the magnitude of the association between depressive symptoms and HED was significant and increased until age 30 (aOR: 1.88, 95% CI: 1.48, 2.39), with associations remaining significant until age 55 (aOR: 1.64, 95% CI: 1.17, 2.29). Women had more variability and higher magnitudes of associations between depressive symptoms and HED than men. The interrelationship between depressive symptoms and HED was significant throughout most of adulthood for PWH receiving HIV care in Cameroon. Understanding age and gender trends in these associations can guide integration efforts in HIV care settings.",
keywords = "Adults, Alcohol misuse, Antiretroviral therapy, Cameroon, HIV, Mental health",
author = "Lancaster, {Kathryn Elizabeth} and Molly Remch and Andrew Edmonds and Rogers Ajeh and Anastase Dzudie and Adebola Adedimeji and Denis Nash and Kathryn Anastos and Marcel Yotebieng and Yone-Pefura, {Eric Walter} and Denis Nsame and Parcesepe, {Angela M.}",
note = "Funding Information: National Institute of Allergy and Infectious Diseases (NIAID), the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Fogarty International Center (FIC), the National Library of Medicine (NLM), and the Office of the Director (OD) under Award Number U01AI096299 (Central Africa-IeDEA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: We used data from the Central Africa-International epidemiology Databases to Evaluate AIDS (CA-IeDEA) study, a clinical cohort of PWH.[] The CA‐IeDEA research consortium, one of seven regional cohorts within IeDEA ( https://www.iedea.org ), is funded by the United States National Institutes of Health to investigate the impact, progression and long‐term outcomes of the HIV/AIDS epidemic in Central Africa. The CA‐IeDEA routinely collects sociodemographic, clinical, and immunological data from the medical records of patients enrolled in HIV care at participating sites in Burundi, Cameroon, Democratic Republic of the Congo (DRC), Republic of Congo (ROC) and Rwanda []. In Cameroon, clinical information, including depressive symptoms and alcohol use, is collected directly from the participants. This retrospective analysis includes data from 18-60-year-old PWH on ART at CA-IeDEA Cameroon sites between January 2016 and March 2020. The IeDEA Cameroon sites included were three HIV treatment centers in Bamenda, Limbe, and Yaounde. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/s10461-022-03939-4",
language = "English (US)",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
}
