Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries

Marcel Yotebieng, Tammy Meyers, Frieda Behets, Mary Ann Davies, Olivia Keiser, Kapella Zacharia Ngonyani, Rita E. Lyamuya, Azar Kariminia, Rawiwan Hansudewechakul, Valeriane Leroy, Sikiratou Koumakpai, Jamie Newman, Annelies Van Rie

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral therapy (ART). We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART. Design: Analysis of data from HIV-infected children younger than 10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS . Methods: The generalized additive model for location, scale, and shape was used to construct normative percentile curves for weight gain at 6, 12, 18, and 24 months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure . Results: Among 7173 children from five regions of the world, 45%were underweight at baseline. Weight gain below the 50th percentile at 6, 12, 18, and 24 months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure . Conclusion: Monitoring weight gain on ART using age-specific and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART .

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalAIDS
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Weight Gain
Therapeutics
HIV
Thinness
Viral Load
Proportional Hazards Models
Acquired Immunodeficiency Syndrome
Databases

Keywords

  • Antiretroviral therapy monitoring
  • CD4<inf>+</inf>
  • Children
  • HIV
  • Lowincome/middle-income countries
  • Viral load
  • Weight

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries. / Yotebieng, Marcel; Meyers, Tammy; Behets, Frieda; Davies, Mary Ann; Keiser, Olivia; Ngonyani, Kapella Zacharia; Lyamuya, Rita E.; Kariminia, Azar; Hansudewechakul, Rawiwan; Leroy, Valeriane; Koumakpai, Sikiratou; Newman, Jamie; Van Rie, Annelies.

In: AIDS, Vol. 29, No. 1, 01.01.2015, p. 101-109.

Research output: Contribution to journalArticle

Yotebieng, M, Meyers, T, Behets, F, Davies, MA, Keiser, O, Ngonyani, KZ, Lyamuya, RE, Kariminia, A, Hansudewechakul, R, Leroy, V, Koumakpai, S, Newman, J & Van Rie, A 2015, 'Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries', AIDS, vol. 29, no. 1, pp. 101-109. https://doi.org/10.1097/QAD.0000000000000506
Yotebieng, Marcel ; Meyers, Tammy ; Behets, Frieda ; Davies, Mary Ann ; Keiser, Olivia ; Ngonyani, Kapella Zacharia ; Lyamuya, Rita E. ; Kariminia, Azar ; Hansudewechakul, Rawiwan ; Leroy, Valeriane ; Koumakpai, Sikiratou ; Newman, Jamie ; Van Rie, Annelies. / Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries. In: AIDS. 2015 ; Vol. 29, No. 1. pp. 101-109.
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abstract = "Background: Viral load and CD4{\%} are often not available in resource-limited settings for monitoring children's responses to antiretroviral therapy (ART). We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART. Design: Analysis of data from HIV-infected children younger than 10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS . Methods: The generalized additive model for location, scale, and shape was used to construct normative percentile curves for weight gain at 6, 12, 18, and 24 months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure . Results: Among 7173 children from five regions of the world, 45{\%}were underweight at baseline. Weight gain below the 50th percentile at 6, 12, 18, and 24 months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure . Conclusion: Monitoring weight gain on ART using age-specific and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART .",
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AU - Davies, Mary Ann

AU - Keiser, Olivia

AU - Ngonyani, Kapella Zacharia

AU - Lyamuya, Rita E.

AU - Kariminia, Azar

AU - Hansudewechakul, Rawiwan

AU - Leroy, Valeriane

AU - Koumakpai, Sikiratou

AU - Newman, Jamie

AU - Van Rie, Annelies

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N2 - Background: Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral therapy (ART). We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART. Design: Analysis of data from HIV-infected children younger than 10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS . Methods: The generalized additive model for location, scale, and shape was used to construct normative percentile curves for weight gain at 6, 12, 18, and 24 months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure . Results: Among 7173 children from five regions of the world, 45%were underweight at baseline. Weight gain below the 50th percentile at 6, 12, 18, and 24 months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure . Conclusion: Monitoring weight gain on ART using age-specific and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART .

AB - Background: Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral therapy (ART). We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART. Design: Analysis of data from HIV-infected children younger than 10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS . Methods: The generalized additive model for location, scale, and shape was used to construct normative percentile curves for weight gain at 6, 12, 18, and 24 months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure . Results: Among 7173 children from five regions of the world, 45%were underweight at baseline. Weight gain below the 50th percentile at 6, 12, 18, and 24 months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure . Conclusion: Monitoring weight gain on ART using age-specific and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART .

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