Age-related changes of muscimol binding in the substantia nigra

John N D Wurpel, Ann Tempel, Ellen F. Sperber, Solomon L. Moshe

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalDevelopmental Brain Research
Volume43
Issue number2
DOIs
StatePublished - Oct 1 1988

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Muscimol
Substantia Nigra
GABA-A Receptors
Cerebellum
Anticonvulsants
Binding Sites

Keywords

  • Animal, newborn
  • Muscimol
  • Rat
  • Substantia nigra
  • γ-Aminobutyric acid receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Age-related changes of muscimol binding in the substantia nigra. / Wurpel, John N D; Tempel, Ann; Sperber, Ellen F.; Moshe, Solomon L.

In: Developmental Brain Research, Vol. 43, No. 2, 01.10.1988, p. 305-308.

Research output: Contribution to journalArticle

Wurpel, John N D ; Tempel, Ann ; Sperber, Ellen F. ; Moshe, Solomon L. / Age-related changes of muscimol binding in the substantia nigra. In: Developmental Brain Research. 1988 ; Vol. 43, No. 2. pp. 305-308.
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