Age-related changes of muscimol binding in the substantia nigra

John N.D. Wurpel, Ann Tempel, Ellen F. Sperber, Solomon L. Moshé

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalDevelopmental Brain Research
Volume43
Issue number2
DOIs
StatePublished - Oct 1 1988

Keywords

  • Animal, newborn
  • Muscimol
  • Rat
  • Substantia nigra
  • γ-Aminobutyric acid receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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