Abstract
Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.
Original language | English (US) |
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Pages (from-to) | 305-308 |
Number of pages | 4 |
Journal | Developmental Brain Research |
Volume | 43 |
Issue number | 2 |
DOIs | |
State | Published - Oct 1 1988 |
Keywords
- Animal, newborn
- Muscimol
- Rat
- Substantia nigra
- γ-Aminobutyric acid receptor
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology