Age-related changes in striatal dopamine activity following nigral muscimol infusions

S. L. Moshe, E. F. Sperber, J. N.D. Wurpel, N. S. Sharpless

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Abstract

Microinfusions of muscimol into the substantia nigra pars reticulata produced marked increases in striatal dopamine (DA) utilization without affecting striatal DA concentration in adult rats. In contrast, muscimol increased striatal DA concentration and decreased DA utilization in 16-day-old rat pups. The striatal norepinephrine concentration was not altered in either group. Since previous studies have shown that similar infusions of muscimol are anticonvulsant in adults and proconvulsant in rat pups, our results suggest that the nigrostriatal pathway may play an important role in mediating the nigral effects on seizures.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalDevelopmental Brain Research
Volume31
Issue number1
Publication statusPublished - Jan 1 1987

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ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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