Aerobic exercise training and inducible inflammation: Results of a randomized controlled trial in healthy, young adults

Richard P. Sloan, Peter A. Shapiro, Paula S. McKinley, Matthew N. Bartels, Daichi Shimbo, Vincenzo Lauriola, Wahida Karmally, Martina Pavlicova, C. Jean Choi, Tse Hwei Choo, Jennifer M. Scodes, Pamela Flood, Kevin J. Tracey

Research output: Contribution to journalArticle

Abstract

Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the antiinflammatory effects of aerobic training elusive. Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-α (TNF-a) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-α (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-α (51% increase, P=0.041) and IL-6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-α (54% decrease, P=0.007) and IL-6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-α or IL-6. Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.

Original languageEnglish (US)
Article numbere010201
JournalJournal of the American Heart Association
Volume7
Issue number17
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Fingerprint

Young Adult
Randomized Controlled Trials
Exercise
Inflammation
Interleukin-6
Lipopolysaccharides
Anti-Inflammatory Agents
Toll-Like Receptor 4
Oxygen Consumption
Tumor Necrosis Factor-alpha
Clinical Trials
Health

Keywords

  • Clinical trial
  • Exercise training
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Aerobic exercise training and inducible inflammation : Results of a randomized controlled trial in healthy, young adults. / Sloan, Richard P.; Shapiro, Peter A.; McKinley, Paula S.; Bartels, Matthew N.; Shimbo, Daichi; Lauriola, Vincenzo; Karmally, Wahida; Pavlicova, Martina; Choi, C. Jean; Choo, Tse Hwei; Scodes, Jennifer M.; Flood, Pamela; Tracey, Kevin J.

In: Journal of the American Heart Association, Vol. 7, No. 17, e010201, 01.09.2018.

Research output: Contribution to journalArticle

Sloan, RP, Shapiro, PA, McKinley, PS, Bartels, MN, Shimbo, D, Lauriola, V, Karmally, W, Pavlicova, M, Choi, CJ, Choo, TH, Scodes, JM, Flood, P & Tracey, KJ 2018, 'Aerobic exercise training and inducible inflammation: Results of a randomized controlled trial in healthy, young adults', Journal of the American Heart Association, vol. 7, no. 17, e010201. https://doi.org/10.1161/JAHA.118.010201
Sloan, Richard P. ; Shapiro, Peter A. ; McKinley, Paula S. ; Bartels, Matthew N. ; Shimbo, Daichi ; Lauriola, Vincenzo ; Karmally, Wahida ; Pavlicova, Martina ; Choi, C. Jean ; Choo, Tse Hwei ; Scodes, Jennifer M. ; Flood, Pamela ; Tracey, Kevin J. / Aerobic exercise training and inducible inflammation : Results of a randomized controlled trial in healthy, young adults. In: Journal of the American Heart Association. 2018 ; Vol. 7, No. 17.
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abstract = "Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the antiinflammatory effects of aerobic training elusive. Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-α (TNF-a) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15{\%} increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-α (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-α (51{\%} increase, P=0.041) and IL-6 (42{\%} increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-α (54{\%} decrease, P=0.007) and IL-6 (55{\%} decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-α or IL-6. Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.",
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AU - Shapiro, Peter A.

AU - McKinley, Paula S.

AU - Bartels, Matthew N.

AU - Shimbo, Daichi

AU - Lauriola, Vincenzo

AU - Karmally, Wahida

AU - Pavlicova, Martina

AU - Choi, C. Jean

AU - Choo, Tse Hwei

AU - Scodes, Jennifer M.

AU - Flood, Pamela

AU - Tracey, Kevin J.

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N2 - Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the antiinflammatory effects of aerobic training elusive. Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-α (TNF-a) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-α (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-α (51% increase, P=0.041) and IL-6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-α (54% decrease, P=0.007) and IL-6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-α or IL-6. Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.

AB - Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the antiinflammatory effects of aerobic training elusive. Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-α (TNF-a) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-α (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-α (51% increase, P=0.041) and IL-6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-α (54% decrease, P=0.007) and IL-6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-α or IL-6. Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.

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