Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

Jeffrey S. Flier, Lisa H. Underhill, Michael Brownlee, Anthony Cerami, Helen Vlassara

Research output: Contribution to journalReview articlepeer-review

2234 Scopus citations

Abstract

IN this seminar we review recent studies suggesting that the central pathologic features of diabetic complications are caused by the hyperglycemia-accelerated formation of nonenzymatic advanced glycosylation end products in tissue. We will emphasize new research findings with important clinical implications, since older information is available in previously published reviews.12 Other biochemical mechanisms by which hyperglycemia may contribute to the development of diabetic complications are not discussed here, since they are comprehensively reviewed elsewhere.3 4 5 6 7 8 Differences between Early and Advanced Glycosylation Products The central pathophysiologic features of diabetic vascular complications are an abnormal leakage of proteins from the circulation and a progressive.

Original languageEnglish (US)
Pages (from-to)1315-1321
Number of pages7
JournalNew England Journal of Medicine
Volume318
Issue number20
DOIs
StatePublished - May 19 1988

ASJC Scopus subject areas

  • Medicine(all)

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