Advanced development of the digital tuberculosis tester for MDR-TB screening

J. E. Smith, M. D. Simkulet, A. Gutin, A. Gutin, S. Bardarov, Jr Jacobs W.R., J. Castracane, O. Tang, Paul F. Riska

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease, and the threat is becoming more critical with the spread of multi-drug resistant Tuberculosis MDR-TB). TB detection, and susceptibility testing for drug resistant strain identification, is advancing with the development of Luciferase Reporter Mycobacteriophages (LRM). Luciferase Reporter Mycobacteriophages will emit visible light at very low intensity when in the presence of live mycobacteria cells such as Tuberculosis strains. InterScience, Inc., together with its collaborators, is developing a highly sensitive, real-time digital detection system for the analysis of luminescent assays. Recent advances in system sensitivity, design, and implementation, as well as preliminary results of the development of individual test cartridges, will be presented. The ultimate goal of this work is to provide a versatile luminescence detection tool for widespread research and clinical applications.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.E. Cohn
Pages9-15
Number of pages7
Volume4255
DOIs
StatePublished - 2001
Externally publishedYes
EventClinical Diagnostic Systems - San Jose, CA, United States
Duration: Jan 21 2001Jan 22 2001

Other

OtherClinical Diagnostic Systems
CountryUnited States
CitySan Jose, CA
Period1/21/011/22/01

Fingerprint

tuberculosis
test equipment
Luminescence
Assays
Screening
screening
Testing
drugs
cartridges
infectious diseases
death
luminescence
magnetic permeability
causes
sensitivity
cells

Keywords

  • Cooled CCD
  • Digital imaging
  • LRM Assay
  • Luminescence
  • Tuberculosis

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Smith, J. E., Simkulet, M. D., Gutin, A., Gutin, A., Bardarov, S., Jacobs W.R., J., ... Riska, P. F. (2001). Advanced development of the digital tuberculosis tester for MDR-TB screening. In G. E. Cohn (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4255, pp. 9-15) https://doi.org/10.1117/12.426753

Advanced development of the digital tuberculosis tester for MDR-TB screening. / Smith, J. E.; Simkulet, M. D.; Gutin, A.; Gutin, A.; Bardarov, S.; Jacobs W.R., Jr; Castracane, J.; Tang, O.; Riska, Paul F.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.E. Cohn. Vol. 4255 2001. p. 9-15.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Smith, JE, Simkulet, MD, Gutin, A, Gutin, A, Bardarov, S, Jacobs W.R., J, Castracane, J, Tang, O & Riska, PF 2001, Advanced development of the digital tuberculosis tester for MDR-TB screening. in GE Cohn (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4255, pp. 9-15, Clinical Diagnostic Systems, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.426753
Smith JE, Simkulet MD, Gutin A, Gutin A, Bardarov S, Jacobs W.R. J et al. Advanced development of the digital tuberculosis tester for MDR-TB screening. In Cohn GE, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4255. 2001. p. 9-15 https://doi.org/10.1117/12.426753
Smith, J. E. ; Simkulet, M. D. ; Gutin, A. ; Gutin, A. ; Bardarov, S. ; Jacobs W.R., Jr ; Castracane, J. ; Tang, O. ; Riska, Paul F. / Advanced development of the digital tuberculosis tester for MDR-TB screening. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.E. Cohn. Vol. 4255 2001. pp. 9-15
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