Adult Height, Prevalent Coronary Artery Calcium Score, and Incident Cardiovascular Disease Outcomes in a Multiethnic Cohort

Joseph Yeboah, Michael J. Blaha, Erin D. Michos, Waqas Qureshi, Michael Miedema, Peter Flueckiger, Carlos J. Rodriguez, Moyses Szklo, Alain G. Bertoni

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We assessed the relationships among adult height, coronary artery calcium (CAC) score, incident atherosclerotic cardiovascular disease (ASCVD) events, and atrial fibrillation (AFib) in a multiethnic cohort. We used race/ethnicityspecific height (dichotomized by median value and in quartiles) as the predictor variable within the 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (n = 6,814). After a mean of 10.2 years of follow-up (2000-2012), 556 ASCVD events (8.2%) and 539 AFib events (7.9%) occurred. Adult height was not associated with prevalent CAC score (ln(CAC + 1) or categories). Tall stature (i.e., race/ethnicity-specific height ≥median) had a significant but opposite association with future ASCVD and AFib (hazard ratios were 0.72 (95% confidence interval: 0.56, 0.92) and 1.38 (95% confidence interval: 1.07, 1.79), respectively). We observed a gradient-response but opposite association between quartiles of race/ethnicity-specific height and ASCVD/AFib events in our multivariable models. A formal test of interaction between race/ethnicity-specific height and sex was not significant in the ASCVD model (P = 0.78) but was significant in the AFibmodel (P = 0.03). Tall stature was associated (in a gradient-response fashion) with reduced risk of ASCVD events and increased risk of AFib. Adult height may signal interactions between genetic and environmental factors and may provide risk information independent of current traditional risk factors and CAC score.

Original languageEnglish (US)
Pages (from-to)935-943
Number of pages9
JournalAmerican Journal of Epidemiology
Volume186
Issue number8
DOIs
StatePublished - Oct 15 2017
Externally publishedYes

Keywords

  • Adult height
  • Atherosclerotic cardiovascular disease
  • Atrial fibrillation
  • Cardiovascular disease
  • Coronary artery calcium score

ASJC Scopus subject areas

  • Epidemiology

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    Yeboah, J., Blaha, M. J., Michos, E. D., Qureshi, W., Miedema, M., Flueckiger, P., Rodriguez, C. J., Szklo, M., & Bertoni, A. G. (2017). Adult Height, Prevalent Coronary Artery Calcium Score, and Incident Cardiovascular Disease Outcomes in a Multiethnic Cohort. American Journal of Epidemiology, 186(8), 935-943. https://doi.org/10.1093/aje/kwx165