Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: Review of the literature

Katherine A. O'Hanlan, Gary L. Goldberg, Joan G. Jones, Carolyn D. Runowicz, Laurence Ehrlich, Lorna Rodriguez-Rodriguez

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Neuroendocrine cell carcinoma of the cervix is a virulent tumor associated with an extremely poor prognosis. Even in clinical Stage I disease, there may be subclinical hematogenous and lymphatic metastases with frequent recurrences. Adjuvant postoperative external pelvic radiotherapy has been reported to offer some degree of local control; however, most patients succumb to distant disease. Following radical abdominal hysterectomy and pelvic lymphadenectomy, with confirmation of the neuroendocrine tumor by electron microscopy and immunohistochemical staining, two patients were given adjuvant systemic chemotherapy with concurrent pelvic radiotherapy, employing regimens with documented activity against small cell carcinoma of the lung of neuroendocrine origin. Despite severe myelotoxicity and persistent neuropathy, both patients are alive without clinical evidence of disease at 28+ and 47+ months.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalGynecologic Oncology
Volume43
Issue number2
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    O'Hanlan, K. A., Goldberg, G. L., Jones, J. G., Runowicz, C. D., Ehrlich, L., & Rodriguez-Rodriguez, L. (1991). Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: Review of the literature. Gynecologic Oncology, 43(2), 167-172. https://doi.org/10.1016/0090-8258(91)90066-E