Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women

Rhonda Arthur, Geoffrey C. Kabat, Mimi Kim, Gloria Y.F. Ho, Rowan T. Chlebowski, Kathy Pan, Thomas E. Rohan

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Abstract

Purpose: The purpose of this study was to examine the association of type II diabetes and anthropometric variables with risk of pancreatic cancer among postmenopausal women. Methods: Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cancer were diagnosed among 156,218 women over a median follow-up of approximately 18 years. Cox proportional hazards models were used to estimate the associations of study factors with pancreatic cancer risk. Results: Diabetes (hazards ratio (HR): 1.30; 95% confidence intervals (95% CI): 1.01–1.66), and in particular, waist circumference, waist-to-hip ratio, and waist-to-height ratio showed positive associations with pancreatic cancer risk (HRs for highest vs. lowest level 1.38; 95% CI: 1.14–1.66, 1.40; 1.17–1.68; and 1.36; 1.13–1.64, respectively). Body mass index at the baseline showed only a borderline positive association with risk (HR: 1.21; 95% CI: 0.97–1.51). Body mass index at age 50 years, but not at ages 18 and 35 years, was also associated with increased pancreatic cancer risk. Conclusions: In this study of postmenopausal women, central adiposity and, to a lesser extent, general adiposity and a history of diabetes, were associated with increased pancreatic cancer risk.

Original languageEnglish (US)
JournalAnnals of Epidemiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Adiposity
Pancreatic Neoplasms
Waist Circumference
Confidence Intervals
Body Mass Index
Weights and Measures
Waist-Hip Ratio
Proportional Hazards Models
Type 2 Diabetes Mellitus
Medical Records
Hip
Odds Ratio
Physicians

Keywords

  • Adiposity
  • Body mass index
  • Cohort studies
  • Diabetes
  • Pancreatic cancer
  • Postmenopausal women
  • Waist circumference
  • Waist-to-hip-ratio

ASJC Scopus subject areas

  • Epidemiology

Cite this

Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women. / Arthur, Rhonda; Kabat, Geoffrey C.; Kim, Mimi; Ho, Gloria Y.F.; Chlebowski, Rowan T.; Pan, Kathy; Rohan, Thomas E.

In: Annals of Epidemiology, 01.01.2018.

Research output: Contribution to journalArticle

Arthur, Rhonda ; Kabat, Geoffrey C. ; Kim, Mimi ; Ho, Gloria Y.F. ; Chlebowski, Rowan T. ; Pan, Kathy ; Rohan, Thomas E. / Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women. In: Annals of Epidemiology. 2018.
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abstract = "Purpose: The purpose of this study was to examine the association of type II diabetes and anthropometric variables with risk of pancreatic cancer among postmenopausal women. Methods: Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cancer were diagnosed among 156,218 women over a median follow-up of approximately 18 years. Cox proportional hazards models were used to estimate the associations of study factors with pancreatic cancer risk. Results: Diabetes (hazards ratio (HR): 1.30; 95{\%} confidence intervals (95{\%} CI): 1.01–1.66), and in particular, waist circumference, waist-to-hip ratio, and waist-to-height ratio showed positive associations with pancreatic cancer risk (HRs for highest vs. lowest level 1.38; 95{\%} CI: 1.14–1.66, 1.40; 1.17–1.68; and 1.36; 1.13–1.64, respectively). Body mass index at the baseline showed only a borderline positive association with risk (HR: 1.21; 95{\%} CI: 0.97–1.51). Body mass index at age 50 years, but not at ages 18 and 35 years, was also associated with increased pancreatic cancer risk. Conclusions: In this study of postmenopausal women, central adiposity and, to a lesser extent, general adiposity and a history of diabetes, were associated with increased pancreatic cancer risk.",
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