TY - JOUR
T1 - Adhesion molecules in the nervous system
T2 - Structural insights into function and diversity
AU - Shapiro, Lawrence
AU - Love, James
AU - Colman, David R.
PY - 2007
Y1 - 2007
N2 - The unparalleled complexity of intercellular connections in the nervous system presents requirements for high levels of both specificity and diversity for the proteins that mediate cell adhesion. Here we describe recent advances toward understanding the molecular mechanisms that underlie adhesive binding, specificity, and diversity for several well-characterized families of adhesion molecules in the nervous system. Although many families of adhesion proteins, including cadherins and immunoglobulin superfamily members, are utilized in neural and nonneural contexts, nervous system-specific diversification mechanisms, such as precisely regulated alternative splicing, provide an important means to enable their function in the complex context of the nervous system.
AB - The unparalleled complexity of intercellular connections in the nervous system presents requirements for high levels of both specificity and diversity for the proteins that mediate cell adhesion. Here we describe recent advances toward understanding the molecular mechanisms that underlie adhesive binding, specificity, and diversity for several well-characterized families of adhesion molecules in the nervous system. Although many families of adhesion proteins, including cadherins and immunoglobulin superfamily members, are utilized in neural and nonneural contexts, nervous system-specific diversification mechanisms, such as precisely regulated alternative splicing, provide an important means to enable their function in the complex context of the nervous system.
KW - Alternative splicing
KW - Cadherin immunoglobulin superfamily
KW - Cell adhesion
KW - Integrin
KW - Neurexin/neuroligin
UR - http://www.scopus.com/inward/record.url?scp=34547668506&partnerID=8YFLogxK
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U2 - 10.1146/annurev.neuro.29.051605.113034
DO - 10.1146/annurev.neuro.29.051605.113034
M3 - Review article
C2 - 17600523
AN - SCOPUS:34547668506
SN - 0147-006X
VL - 30
SP - 451
EP - 474
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
ER -