Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women

Mark H. Kuniholm, Edgar Ong, Boris M. Hogema, Marco Koppelman, Kathryn Anastos, Marion G. Peters, Eric C. Seaberg, Yue Chen, Kenrad E. Nelson, Jeffrey M. Linnen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S. populations. We tested 2,919 plasma samples collected from HIV-infected (HIV+) women and men enrolled in U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT+ samples were confirmed by real-time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV+ women and men, respectively. All HEV isolates were genotype 3a. Based on follow-up testing of stored samples, 1 woman had chronic HEV infection for >4 years whereas 2 women had acute HEV detectable at only a single study visit. Conclusions: To our knowledge, this is the first reported case of chronic HEV infection in an HIV+ U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4+ count >200 cells/mm3. These data suggest that HEV infection is rare in the HIV+ U.S. population.

Original languageEnglish (US)
JournalHepatology
DOIs
StateAccepted/In press - 2016

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Hepatitis E virus
Virus Diseases
Chronic Hepatitis
HIV
Viremia
Nucleic Acids
CD4 Lymphocyte Count
Coinfection
Population
Liver Diseases
Real-Time Polymerase Chain Reaction
Cohort Studies
Biomarkers
Genotype

ASJC Scopus subject areas

  • Hepatology

Cite this

Kuniholm, M. H., Ong, E., Hogema, B. M., Koppelman, M., Anastos, K., Peters, M. G., ... Linnen, J. M. (Accepted/In press). Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women. Hepatology. https://doi.org/10.1002/hep.28384

Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women. / Kuniholm, Mark H.; Ong, Edgar; Hogema, Boris M.; Koppelman, Marco; Anastos, Kathryn; Peters, Marion G.; Seaberg, Eric C.; Chen, Yue; Nelson, Kenrad E.; Linnen, Jeffrey M.

In: Hepatology, 2016.

Research output: Contribution to journalArticle

Kuniholm, MH, Ong, E, Hogema, BM, Koppelman, M, Anastos, K, Peters, MG, Seaberg, EC, Chen, Y, Nelson, KE & Linnen, JM 2016, 'Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women', Hepatology. https://doi.org/10.1002/hep.28384
Kuniholm, Mark H. ; Ong, Edgar ; Hogema, Boris M. ; Koppelman, Marco ; Anastos, Kathryn ; Peters, Marion G. ; Seaberg, Eric C. ; Chen, Yue ; Nelson, Kenrad E. ; Linnen, Jeffrey M. / Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women. In: Hepatology. 2016.
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