Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women

Mark H. Kuniholm, Edgar Ong, Boris M. Hogema, Marco Koppelman, Kathryn Anastos, Marion G. Peters, Eric C. Seaberg, Yue Chen, Kenrad E. Nelson, Jeffrey M. Linnen

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25 Scopus citations

Abstract

Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S. populations. We tested 2,919 plasma samples collected from HIV-infected (HIV+) women and men enrolled in U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT+ samples were confirmed by real-time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV+ women and men, respectively. All HEV isolates were genotype 3a. Based on follow-up testing of stored samples, 1 woman had chronic HEV infection for >4 years whereas 2 women had acute HEV detectable at only a single study visit. Conclusions: To our knowledge, this is the first reported case of chronic HEV infection in an HIV+ U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4+ count >200 cells/mm3. Overall, though, these data suggest that HEV infection is rare in the HIV+ U.S. population.

Original languageEnglish (US)
Pages (from-to)712-720
Number of pages9
JournalHepatology
Volume63
Issue number3
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Hepatology

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Kuniholm, M. H., Ong, E., Hogema, B. M., Koppelman, M., Anastos, K., Peters, M. G., Seaberg, E. C., Chen, Y., Nelson, K. E., & Linnen, J. M. (2016). Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women. Hepatology, 63(3), 712-720. https://doi.org/10.1002/hep.28384