Active currents regulate sensitivity and dynamic range in C. elegans Neurons

Miriam B. Goodman, David H. Hall, Leon Avery, Shawn R. Lockery

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Little is known about the physiology of neurons in Caenorhabditis elegans. Using new techniques for in situ patch-clamp recording in C. elegans, we analyzed the electrical properties of an identified sensory neuron (ASER) across four developmental stages and 42 unidentified neurons at one stage. We find that ASER is nearly isopotential and fails to generate classical Na+ action potentials. Rather, ASER displays a high sensitivity to input currents coupled to a depolarization-dependent reduction in sensitivity that may endow ASER with a wide dynamic range. Voltage clamp revealed depolarization-activated K+ and Ca2+ currents that contribute to high sensitivity near the zero-current potential. The depolarization-dependent reduction in sensitivity can be attributed to activation of K+ current at voltages where it dominates the net membrane current. The voltage dependence of membrane current was similar in all neurons examined, suggesting that C. elegans neurons share a common mechanism of sensitivity and dynamic range.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
JournalNeuron
Volume20
Issue number4
DOIs
StatePublished - Apr 1998

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Caenorhabditis elegans
Neurons
Membranes
Sensory Receptor Cells
Action Potentials

ASJC Scopus subject areas

  • Neuroscience(all)

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Active currents regulate sensitivity and dynamic range in C. elegans Neurons. / Goodman, Miriam B.; Hall, David H.; Avery, Leon; Lockery, Shawn R.

In: Neuron, Vol. 20, No. 4, 04.1998, p. 763-772.

Research output: Contribution to journalArticle

Goodman, Miriam B. ; Hall, David H. ; Avery, Leon ; Lockery, Shawn R. / Active currents regulate sensitivity and dynamic range in C. elegans Neurons. In: Neuron. 1998 ; Vol. 20, No. 4. pp. 763-772.
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