Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children

Catherine Manix Feintuch, Alex Saidi, Karl Seydel, Grace Chen, Adam Goldman-Yassen, Neida K. Mita-Mendoza, Ryung S. Kim, Paul S. Frenette, Terrie Taylor, Johanna P. Daily

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparuminfected red blood cells (iRBCs). Although many young children are infected with P. falciparum, CM remains a rare outcome; thus, we hypothesized that specific host conditions facilitate iRBC cerebral sequestration. To identify these host factors, we compared the peripheral whole-blood transcriptomes of Malawian children with iRBC cerebral sequestration, identified as malarialretinopathy- positive CM (Ret+CM), to the transcriptomes of children with CM and no cerebral iRBC sequestration, defined as malarial-retinopathy-negative CM (Ret-CM). Ret+CM was associated with upregulation of 103 gene set pathways, including cytokine, blood coagulation, and extracellular matrix (ECM) pathways (P

Original languageEnglish (US)
Article numbere01300-15
JournalmBio
Volume7
Issue number1
DOIs
StatePublished - Feb 16 2016

Fingerprint

Cerebral Malaria
Neutrophils
Pediatrics
Transcriptome
Plasmodium
Falciparum Malaria
Blood Coagulation
Extracellular Matrix
Up-Regulation
Erythrocytes
Cytokines

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Feintuch, C. M., Saidi, A., Seydel, K., Chen, G., Goldman-Yassen, A., Mita-Mendoza, N. K., ... Daily, J. P. (2016). Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. mBio, 7(1), [e01300-15]. https://doi.org/10.1128/mBio.01300-15

Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. / Feintuch, Catherine Manix; Saidi, Alex; Seydel, Karl; Chen, Grace; Goldman-Yassen, Adam; Mita-Mendoza, Neida K.; Kim, Ryung S.; Frenette, Paul S.; Taylor, Terrie; Daily, Johanna P.

In: mBio, Vol. 7, No. 1, e01300-15, 16.02.2016.

Research output: Contribution to journalArticle

Feintuch, CM, Saidi, A, Seydel, K, Chen, G, Goldman-Yassen, A, Mita-Mendoza, NK, Kim, RS, Frenette, PS, Taylor, T & Daily, JP 2016, 'Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children', mBio, vol. 7, no. 1, e01300-15. https://doi.org/10.1128/mBio.01300-15
Feintuch CM, Saidi A, Seydel K, Chen G, Goldman-Yassen A, Mita-Mendoza NK et al. Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. mBio. 2016 Feb 16;7(1). e01300-15. https://doi.org/10.1128/mBio.01300-15
Feintuch, Catherine Manix ; Saidi, Alex ; Seydel, Karl ; Chen, Grace ; Goldman-Yassen, Adam ; Mita-Mendoza, Neida K. ; Kim, Ryung S. ; Frenette, Paul S. ; Taylor, Terrie ; Daily, Johanna P. / Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. In: mBio. 2016 ; Vol. 7, No. 1.
@article{597c6eb650a54407bf8e7db663b6fc87,
title = "Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children",
abstract = "Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparuminfected red blood cells (iRBCs). Although many young children are infected with P. falciparum, CM remains a rare outcome; thus, we hypothesized that specific host conditions facilitate iRBC cerebral sequestration. To identify these host factors, we compared the peripheral whole-blood transcriptomes of Malawian children with iRBC cerebral sequestration, identified as malarialretinopathy- positive CM (Ret+CM), to the transcriptomes of children with CM and no cerebral iRBC sequestration, defined as malarial-retinopathy-negative CM (Ret-CM). Ret+CM was associated with upregulation of 103 gene set pathways, including cytokine, blood coagulation, and extracellular matrix (ECM) pathways (P",
author = "Feintuch, {Catherine Manix} and Alex Saidi and Karl Seydel and Grace Chen and Adam Goldman-Yassen and Mita-Mendoza, {Neida K.} and Kim, {Ryung S.} and Frenette, {Paul S.} and Terrie Taylor and Daily, {Johanna P.}",
year = "2016",
month = "2",
day = "16",
doi = "10.1128/mBio.01300-15",
language = "English (US)",
volume = "7",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children

AU - Feintuch, Catherine Manix

AU - Saidi, Alex

AU - Seydel, Karl

AU - Chen, Grace

AU - Goldman-Yassen, Adam

AU - Mita-Mendoza, Neida K.

AU - Kim, Ryung S.

AU - Frenette, Paul S.

AU - Taylor, Terrie

AU - Daily, Johanna P.

PY - 2016/2/16

Y1 - 2016/2/16

N2 - Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparuminfected red blood cells (iRBCs). Although many young children are infected with P. falciparum, CM remains a rare outcome; thus, we hypothesized that specific host conditions facilitate iRBC cerebral sequestration. To identify these host factors, we compared the peripheral whole-blood transcriptomes of Malawian children with iRBC cerebral sequestration, identified as malarialretinopathy- positive CM (Ret+CM), to the transcriptomes of children with CM and no cerebral iRBC sequestration, defined as malarial-retinopathy-negative CM (Ret-CM). Ret+CM was associated with upregulation of 103 gene set pathways, including cytokine, blood coagulation, and extracellular matrix (ECM) pathways (P

AB - Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparuminfected red blood cells (iRBCs). Although many young children are infected with P. falciparum, CM remains a rare outcome; thus, we hypothesized that specific host conditions facilitate iRBC cerebral sequestration. To identify these host factors, we compared the peripheral whole-blood transcriptomes of Malawian children with iRBC cerebral sequestration, identified as malarialretinopathy- positive CM (Ret+CM), to the transcriptomes of children with CM and no cerebral iRBC sequestration, defined as malarial-retinopathy-negative CM (Ret-CM). Ret+CM was associated with upregulation of 103 gene set pathways, including cytokine, blood coagulation, and extracellular matrix (ECM) pathways (P

UR - http://www.scopus.com/inward/record.url?scp=84960192311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960192311&partnerID=8YFLogxK

U2 - 10.1128/mBio.01300-15

DO - 10.1128/mBio.01300-15

M3 - Article

C2 - 26884431

AN - SCOPUS:84960192311

VL - 7

JO - mBio

JF - mBio

SN - 2161-2129

IS - 1

M1 - e01300-15

ER -