Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children

Catherine Manix Feintuch, Alex Saidi, Karl Seydel, Grace Chen, Adam Goldman-Yassen, Neida K. Mita-Mendoza, Ryung S. Kim, Paul S. Frenette, Terrie Taylor, Johanna P. Daily

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25 Scopus citations

Abstract

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparuminfected red blood cells (iRBCs). Although many young children are infected with P. falciparum, CM remains a rare outcome; thus, we hypothesized that specific host conditions facilitate iRBC cerebral sequestration. To identify these host factors, we compared the peripheral whole-blood transcriptomes of Malawian children with iRBC cerebral sequestration, identified as malarialretinopathy- positive CM (Ret+CM), to the transcriptomes of children with CM and no cerebral iRBC sequestration, defined as malarial-retinopathy-negative CM (Ret-CM). Ret+CM was associated with upregulation of 103 gene set pathways, including cytokine, blood coagulation, and extracellular matrix (ECM) pathways (P

Original languageEnglish (US)
Article numbere01300-15
JournalmBio
Volume7
Issue number1
DOIs
Publication statusPublished - Feb 16 2016

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ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Feintuch, C. M., Saidi, A., Seydel, K., Chen, G., Goldman-Yassen, A., Mita-Mendoza, N. K., ... Daily, J. P. (2016). Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. mBio, 7(1), [e01300-15]. https://doi.org/10.1128/mBio.01300-15