Actions of toxins on cerebral metabolism at the cellular level

U. Sonnewald, T. Syversen, A. Schousboe, H. Waagepetersen, M. Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell-specific manner, which is the case for MSO acting mostly on astrocytes, whereas MeHg, AOAA, and 3-NPA exert their effects mostly on neurons. In the case of MeHg this effect is possibly mediated via astrocytes. The adverse cellular effects of these toxic compounds can be used for probing metabolism and creating animal models of disease, thus providing means for a better understanding of the etiology of neurological disorders, as well as for testing the effectiveness of potential treatment modalities.

Original languageEnglish (US)
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology
Subtitle of host publicationBrain Energetics. Integration of Molecular and Cellular Processes
PublisherSpringer US
Pages569-585
Number of pages17
ISBN (Print)9780387303468
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Sonnewald, U., Syversen, T., Schousboe, A., Waagepetersen, H., & Aschner, M. (2007). Actions of toxins on cerebral metabolism at the cellular level. In Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes (pp. 569-585). Springer US. https://doi.org/10.1007/978-0-387-30411-3_21