TY - JOUR
T1 - Actin dynamics at the Golgi complex in mammalian cells
AU - Egea, Gustavo
AU - Lázaro-Diéguez, Francisco
AU - Vilella, Montserrat
N1 - Funding Information:
Thanks to Rosa Ríos, Erwin Knech and Susana E. Martínez for comments on the manuscript. This work received financial support from the Ministerio de Educación y Ciencia (SAF and BMC programmes), the European Commission (contract RTN2002-259), and the Generalitat de Catalunya-DURSI (Distinció per la Recerca). Dedicated to the everlasting memory of Valentí Costa (1963-2005) and Senén Vilaró (1956-2005).
PY - 2006/4
Y1 - 2006/4
N2 - Secretion and endocytosis are highly dynamic processes that are sensitive to external stimuli. Thus, in multicellular organisms, different cell types utilize specialised pathways of intracellular membrane traffic to facilitate specific physiological functions. In addition to the complex internal molecular factors that govern sorting functions and fission or fusion of transport carriers, the actin cytoskeleton plays an important role in both the endocytic and secretory pathways. The interaction between the actin cytoskeleton and membrane trafficking is not restricted to transport processes: it also appears to be directly involved in the biogenesis of Golgi-derived transport carriers (budding and fission processes) and in the maintenance of the unique flat shape of Golgi cisternae.
AB - Secretion and endocytosis are highly dynamic processes that are sensitive to external stimuli. Thus, in multicellular organisms, different cell types utilize specialised pathways of intracellular membrane traffic to facilitate specific physiological functions. In addition to the complex internal molecular factors that govern sorting functions and fission or fusion of transport carriers, the actin cytoskeleton plays an important role in both the endocytic and secretory pathways. The interaction between the actin cytoskeleton and membrane trafficking is not restricted to transport processes: it also appears to be directly involved in the biogenesis of Golgi-derived transport carriers (budding and fission processes) and in the maintenance of the unique flat shape of Golgi cisternae.
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U2 - 10.1016/j.ceb.2006.02.007
DO - 10.1016/j.ceb.2006.02.007
M3 - Review article
C2 - 16488588
AN - SCOPUS:33644873004
SN - 0955-0674
VL - 18
SP - 168
EP - 178
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -