Actin dynamics at the Golgi complex in mammalian cells

Gustavo Egea, Francisco Lázaro-Diéguez, Montserrat Vilella

Research output: Contribution to journalReview article

138 Scopus citations

Abstract

Secretion and endocytosis are highly dynamic processes that are sensitive to external stimuli. Thus, in multicellular organisms, different cell types utilize specialised pathways of intracellular membrane traffic to facilitate specific physiological functions. In addition to the complex internal molecular factors that govern sorting functions and fission or fusion of transport carriers, the actin cytoskeleton plays an important role in both the endocytic and secretory pathways. The interaction between the actin cytoskeleton and membrane trafficking is not restricted to transport processes: it also appears to be directly involved in the biogenesis of Golgi-derived transport carriers (budding and fission processes) and in the maintenance of the unique flat shape of Golgi cisternae.

Original languageEnglish (US)
Pages (from-to)168-178
Number of pages11
JournalCurrent Opinion in Cell Biology
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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