Acrylonitrile

S. Caito; L. G. Costa; L. U. Rongzhu; M. Aschner

doi:10.1016/B978-0-12-385157-4.00245-1

Acrylonitrile

S. Caito, L. G. Costa, L. U. Rongzhu, M. Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Acrylonitrile is a colorless chemical mainly produced by the ammoxidation of propylene used as a raw material in the manufacture of plastics, resins, and nitriles. Exposure to acrylonitrile has been shown to cause death and neurological dysfunction partly similar to cyanide poisoning. In this article, authors review the sources of acrylonitrile exposure, metabolism, and elimination in humans, as well as its neurological effects and underlying mechanisms of its toxicity.

Original language	English (US)
Title of host publication	Encyclopedia of the Neurological Sciences
Publisher	Elsevier Inc.
Pages	33-35
Number of pages	3
ISBN (Electronic)	9780123851574
ISBN (Print)	9780123851581
DOIs	https://doi.org/10.1016/B978-0-12-385157-4.00245-1
State	Published - Jan 1 2014

Keywords

2-Cyanoethylene
Cyanide
Cytochrome P450 CYP2E1
Glutathione S-transferase
Glutathione conjugate
Glutathione depletion
Industrial chemicals
Neurotoxicology
Oxidative stress
Plastics

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-385157-4.00245-1

Cite this

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title = "Acrylonitrile",

abstract = "Acrylonitrile is a colorless chemical mainly produced by the ammoxidation of propylene used as a raw material in the manufacture of plastics, resins, and nitriles. Exposure to acrylonitrile has been shown to cause death and neurological dysfunction partly similar to cyanide poisoning. In this article, authors review the sources of acrylonitrile exposure, metabolism, and elimination in humans, as well as its neurological effects and underlying mechanisms of its toxicity.",

keywords = "2-Cyanoethylene, Cyanide, Cytochrome P450 CYP2E1, Glutathione S-transferase, Glutathione conjugate, Glutathione depletion, Industrial chemicals, Neurotoxicology, Oxidative stress, Plastics",

author = "S. Caito and Costa, {L. G.} and Rongzhu, {L. U.} and M. Aschner",

year = "2014",

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T1 - Acrylonitrile

AU - Caito, S.

AU - Costa, L. G.

AU - Rongzhu, L. U.

AU - Aschner, M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Acrylonitrile is a colorless chemical mainly produced by the ammoxidation of propylene used as a raw material in the manufacture of plastics, resins, and nitriles. Exposure to acrylonitrile has been shown to cause death and neurological dysfunction partly similar to cyanide poisoning. In this article, authors review the sources of acrylonitrile exposure, metabolism, and elimination in humans, as well as its neurological effects and underlying mechanisms of its toxicity.

AB - Acrylonitrile is a colorless chemical mainly produced by the ammoxidation of propylene used as a raw material in the manufacture of plastics, resins, and nitriles. Exposure to acrylonitrile has been shown to cause death and neurological dysfunction partly similar to cyanide poisoning. In this article, authors review the sources of acrylonitrile exposure, metabolism, and elimination in humans, as well as its neurological effects and underlying mechanisms of its toxicity.

KW - 2-Cyanoethylene

KW - Cyanide

KW - Cytochrome P450 CYP2E1

KW - Glutathione S-transferase

KW - Glutathione conjugate

KW - Glutathione depletion

KW - Industrial chemicals

KW - Neurotoxicology

KW - Oxidative stress

KW - Plastics

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DO - 10.1016/B978-0-12-385157-4.00245-1

M3 - Chapter

AN - SCOPUS:85043297982

SN - 9780123851581

SP - 33

EP - 35

BT - Encyclopedia of the Neurological Sciences

PB - Elsevier Inc.

ER -

Acrylonitrile

Abstract

Keywords

ASJC Scopus subject areas

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