Acquired Methemoglobinemia

The Relationship of Cause to Course of Illness

Jeffrey R. Avner, Fred M. Henretig, Constance M. Mcaneney

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To better characterize methemoglobinemia in children, we reviewed the charts of 17 patients who were admitted to a children's hospital over the last 10 years. Two distinct groups were identified: (1) The endogenous group (n = 9) included patients with methemoglobinemia associated with an intercurrent illness. (2) The exogenous group (n = 8) included patients with methemoglobinemia secondary to drug exposure. Despite similar initial methemoglobin levels in the endogenous (mean, 29%) and exogenous (mean, 28%) groups, children in the endogenous group had more acidosis (serum bicarbonate levels of 5.9 vs 19.1 mmol/L and arterial pH of 7.01 vs 7.35). All the children in the exogenous group with methemoglobinemia secondary to an accidental ingestion stayed only 1 day in the hospital, while children in the endogenous group were admitted for an average of 19 days. Children with methemoglobinemia secondary to a drug exposure have a more benign illness with a shorter duration than children with methemoglobinemia associated with an intercurrent illness. It appears that the absolute level of methemoglobin is not as important as the underlying cause in determining both the course and severity of illness.

Original languageEnglish (US)
Pages (from-to)1229-1230
Number of pages2
JournalAmerican Journal of Diseases of Children
Volume144
Issue number11
DOIs
StatePublished - 1990

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Methemoglobinemia
Methemoglobin
Bicarbonates
Acidosis
Pharmaceutical Preparations
Eating
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Acquired Methemoglobinemia : The Relationship of Cause to Course of Illness. / Avner, Jeffrey R.; Henretig, Fred M.; Mcaneney, Constance M.

In: American Journal of Diseases of Children, Vol. 144, No. 11, 1990, p. 1229-1230.

Research output: Contribution to journalArticle

Avner, Jeffrey R. ; Henretig, Fred M. ; Mcaneney, Constance M. / Acquired Methemoglobinemia : The Relationship of Cause to Course of Illness. In: American Journal of Diseases of Children. 1990 ; Vol. 144, No. 11. pp. 1229-1230.
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