Achondroplasia and obstructive sleep apnea: Correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy

S. J. Goldstein, R. J. Shprintzen, R. H.K. Wu, M. J. Thorpy, S. Y. Hahm, R. Marion, A. E. Sher, P. Saenger

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Severe obstructive sleep apnea in a patient with achondroplasia syndrome was found to result in a definitive deficiency of overnight growth hormone secretion related to absence of slow-wave sleep. Resolution of the apnea by tracheostomy resulted in normalization of growth hormone release and normal growth rates postoperatively. Sleep-related growth hormone deficiency may contribute to the short stature so often seen in a variety of craniofacial syndromes. Furthermore, this short stature may be reversible.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalBirth Defects: Original Article Series
Volume21
Issue number2
StatePublished - Dec 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Achondroplasia and obstructive sleep apnea: Correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy'. Together they form a unique fingerprint.

Cite this