Achondroplasia and obstructive sleep apnea: Correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy

S. J. Goldstein, R. J. Shprintzen, R. H K Wu, Michael J. Thorpy, S. Y. Hahm, Robert W. Marion, A. E. Sher, P. Saenger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Severe obstructive sleep apnea in a patient with achondroplasia syndrome was found to result in a definitive deficiency of overnight growth hormone secretion related to absence of slow-wave sleep. Resolution of the apnea by tracheostomy resulted in normalization of growth hormone release and normal growth rates postoperatively. Sleep-related growth hormone deficiency may contribute to the short stature so often seen in a variety of craniofacial syndromes. Furthermore, this short stature may be reversible.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalBirth Defects: Original Article Series
Volume21
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Achondroplasia
Tracheostomy
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Growth Hormone
Sleep
Apnea
Growth

ASJC Scopus subject areas

  • Genetics(clinical)
  • Developmental Biology

Cite this

Achondroplasia and obstructive sleep apnea : Correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy. / Goldstein, S. J.; Shprintzen, R. J.; Wu, R. H K; Thorpy, Michael J.; Hahm, S. Y.; Marion, Robert W.; Sher, A. E.; Saenger, P.

In: Birth Defects: Original Article Series, Vol. 21, No. 2, 1985, p. 93-101.

Research output: Contribution to journalArticle

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