ACE2 as therapy for glomerular disease: the devil is in the detail

Michael J. Ross, Masaomi Nangaku

Research output: Contribution to journalComment/debate

8 Scopus citations

Abstract

Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

Original languageEnglish (US)
Pages (from-to)1269-1271
Number of pages3
JournalKidney International
Volume91
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)
  • Nephrology

Cite this