Acantholytic dermatosis of the crural folds with ATP2C1 mutation is a possible variant of Hailey-Hailey disease

Jules B. Lipoff, Adarsh V. Mudgil, Saryna Young, Paul Chu, Steven R. Cohen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: We describe a patient with acantholytic dermatosis of the crural folds (ADCF) that was misdiagnosed and treated as condyloma acuminata for 13 years. After many skin biopsies consistently showed epidermal acantholysis and negative human papillomavirus serotyping excluded condyloma acuminata, a diagnosis of ADCF was considered most likely. Objective and Conclusion: Acitretin effectively suppressed the symptomatic hyperkeratosis. Subsequent genetic testing revealed a deletion in the ATP2C1 gene that led us to conclude that this case of ADCF is probably a variant of familial benign chronic pemphigus (Hailey-Hailey disease).

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalJournal of Cutaneous Medicine and Surgery
Volume13
Issue number3
DOIs
StatePublished - 2009

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Benign Familial Pemphigus
Skin Diseases
Condylomata Acuminata
Leg
Mutation
Acantholysis
Acitretin
Serotyping
Genetic Testing
Diagnostic Errors
Biopsy
Skin
Genes

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Acantholytic dermatosis of the crural folds with ATP2C1 mutation is a possible variant of Hailey-Hailey disease. / Lipoff, Jules B.; Mudgil, Adarsh V.; Young, Saryna; Chu, Paul; Cohen, Steven R.

In: Journal of Cutaneous Medicine and Surgery, Vol. 13, No. 3, 2009, p. 151-154.

Research output: Contribution to journalArticle

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