Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis

Ralf Kronenwett, Thorsten Gräf, Frank Neumann, Sabrina Pechtel, Ulrich Steidl, Elena Diaz-Blanco, Rainer Haas

Research output: Contribution to journalLetter

6 Scopus citations

Abstract

In this study, we examined highly enriched CD34+ cells from patients with BCR-ABL-positve CML in chronic phase or blast crisis for the JAK2 V617F activation mutation by sequencing. The cells examined did not bear the mutation irrespective of the disease stage. This finding suggests that the previously described increase of expression and kinase activity of JAK2 in CML cells does not result from the JAK2 V617F activation mutation and that transformation into blast crisis is not associated with the occurrence of this mutation.

Original languageEnglish (US)
Pages (from-to)1323-1324
Number of pages2
JournalLeukemia Research
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Blast crisis
  • CD34+ cells
  • CML
  • JAK2

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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