Abnormalities of the coronary microcirculation in acute murine Chagas' disease

S. M. Factor, S. Cho, M. Wittner, H. Tanowitz

Research output: Contribution to journalArticle

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Abstract

Chronic Chagasic heart disease has many features characteristic of other congestive cardiomyopathies, including ventricular and atrial chamber enlargement, hypertrophy, focal scarring, and mural thrombi. Histologically, there is often lymphocytic inflammation, spotty necrosis, and few parasites. Although immunologic mechanisms have been invoked to explain the development of myocardial degeneration, there have been suggestions that the focal alterations in the heart are secondary to abnormalities of the coronary microcirculation. Based on work from our laboratories which has demonstrated microvascular hyperreactivity in several other models of congestive cardiomyopathy, we investigated whether the cardiac microcirculation of mice acutely infected with Trypanosoma cruzi was also abnormal. We perfused animals at 15-17 days post-infection with silicone rubber which fills the arterioles, capillaries, and venules of the beating heart. After clearing the tissue, we observed numerous areas of focal vascular constriction, microaneurysm formation, dilatation, and proliferation of microvessels which were not present in control animals. These lesions were similar to those we have observed in other congestive cardiomyopathies. Since at this stage of infection there is minimal cardiac degeneration or fibrosis, the presence of these vascular lesions even early in Chagas' disease, may be significant for the pathogenesis of focal myocardial damage. These observations during acute infection provide additional support for the suggestions of others that the myocardial microcirculation is abnormal in Chagas' disease.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume34
Issue number2
StatePublished - 1985

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Chagas Disease
Dilated Cardiomyopathy
Microcirculation
Blood Vessels
Infection
Silicone Elastomers
Venules
Trypanosoma cruzi
Arterioles
Microvessels
Constriction
Hypertrophy
Cicatrix
Dilatation
Heart Diseases
Parasites
Thrombosis
Fibrosis
Necrosis
Inflammation

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Abnormalities of the coronary microcirculation in acute murine Chagas' disease. / Factor, S. M.; Cho, S.; Wittner, M.; Tanowitz, H.

In: American Journal of Tropical Medicine and Hygiene, Vol. 34, No. 2, 1985, p. 246-253.

Research output: Contribution to journalArticle

Factor, SM, Cho, S, Wittner, M & Tanowitz, H 1985, 'Abnormalities of the coronary microcirculation in acute murine Chagas' disease', American Journal of Tropical Medicine and Hygiene, vol. 34, no. 2, pp. 246-253.
Factor, S. M. ; Cho, S. ; Wittner, M. ; Tanowitz, H. / Abnormalities of the coronary microcirculation in acute murine Chagas' disease. In: American Journal of Tropical Medicine and Hygiene. 1985 ; Vol. 34, No. 2. pp. 246-253.
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