Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia

Manuel Arteta, Andrew Campbell, Mehdi Nouraie, Sohail Rana, Onyinye C. Onyekwere, Gregory Ensing, Craig Sable, Niti Dham, Deepika Darbari, Lori Luchtman-Jones, Gregory J. Kato, Mark T. Gladwin, Oswaldo L. Castro, Caterina P. Minniti, Victor R. Gordeuk

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Obstructive and restrictive pulmonary changes develop in children with sickle cell disease, but reports conflict as to the type of change that predominates. We prospectively performed spirometry, plethysmography, and lung diffusing capacity in 146 children aged 7 to 20 years with hemoglobin SS or Sβ-thalassemia. Nineteen percent of the patients had obstructive physiology as defined according to guidelines of the American Thoracic Society. In addition, 9% had restrictive physiology and 11% had abnormal but not categorized physiology. Increasing age, patient-reported or family-reported history of asthma or wheezing, and higher lactate dehydrogenase concentration were independent predictors of obstruction as reflected in lower forced expiratory volume in the first second/forced vital capacity. In conclusion, abnormal pulmonary function, most often obstructive, is common in children with hemoglobin SS and Sβ-thalassemia. Full pulmonary function testing should be performed in children with hemoglobin SS or Sβ-thalassemia, especially with history of asthma or wheezing and accentuated elevations in hemolytic markers.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume36
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Sickle Hemoglobin
Sickle Cell Anemia
Lung
Thalassemia
Respiratory Sounds
Asthma
Lung Volume Measurements
Plethysmography
Spirometry
Vital Capacity
Forced Expiratory Volume
L-Lactate Dehydrogenase
Guidelines

Keywords

  • lactate dehydrogenase
  • obstructive pulmonary function
  • pulmonary function tests
  • reticulocyte count
  • Sickle cell anemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia. / Arteta, Manuel; Campbell, Andrew; Nouraie, Mehdi; Rana, Sohail; Onyekwere, Onyinye C.; Ensing, Gregory; Sable, Craig; Dham, Niti; Darbari, Deepika; Luchtman-Jones, Lori; Kato, Gregory J.; Gladwin, Mark T.; Castro, Oswaldo L.; Minniti, Caterina P.; Gordeuk, Victor R.

In: Journal of Pediatric Hematology/Oncology, Vol. 36, No. 3, 2014, p. 185-189.

Research output: Contribution to journalArticle

Arteta, M, Campbell, A, Nouraie, M, Rana, S, Onyekwere, OC, Ensing, G, Sable, C, Dham, N, Darbari, D, Luchtman-Jones, L, Kato, GJ, Gladwin, MT, Castro, OL, Minniti, CP & Gordeuk, VR 2014, 'Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia', Journal of Pediatric Hematology/Oncology, vol. 36, no. 3, pp. 185-189. https://doi.org/10.1097/MPH.0000000000000011
Arteta, Manuel ; Campbell, Andrew ; Nouraie, Mehdi ; Rana, Sohail ; Onyekwere, Onyinye C. ; Ensing, Gregory ; Sable, Craig ; Dham, Niti ; Darbari, Deepika ; Luchtman-Jones, Lori ; Kato, Gregory J. ; Gladwin, Mark T. ; Castro, Oswaldo L. ; Minniti, Caterina P. ; Gordeuk, Victor R. / Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia. In: Journal of Pediatric Hematology/Oncology. 2014 ; Vol. 36, No. 3. pp. 185-189.
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