Aberrant activation-induced cytidine deaminase expression in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia

Yang Shi, Xiaoxian Zhao, Lisa Durkin, Heesun Joyce Rogers, Eric D. Hsi

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Summary Activation-induced cytidine deaminase (AID) is expressed in germinal center B cells and plays a critical role in somatic hypermutation and class-switch recombination of immunoglobulin genes. Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) carries a poor prognosis and is specifically treated with tyrosine kinase inhibitors. Interestingly, AID has been shown to be aberrantly expressed and functional in Ph+ ALL and is thought to contribute to genetic instability. We hypothesized that AID might be detectable in routinely processed bone marrow biopsies by immunohistochemistry (IHC) and assist in identifying Ph+ ALL. We found that AID was expressed in 26 (70%) of 37 cases of Ph+ ALL but only 1 (2.9%) of 38 cases of Ph- ALL cases. There was a significant difference in AID expression between these 2 ALL groups (P

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalHuman Pathology
Volume52
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Keywords

  • Activation-induced cytidine deaminase
  • Acute lymphoblastic leukemia
  • BCR-ABL1
  • Immunohistochemistry
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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