A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus

Siradanahalli C. Guru, Sunita K. Agarwal, Pachiappan Manickam, Shodimu Emmanuel Olufemi, Judy S. Crabtree, Jane M. Weisemann, Mary Beth Kester, Young S. Kim, Yingping Wang, Michael R. Emmert-Buck, Lance A. Liotta, Allen M. Spiegel, Mark S. Boguski, Bruce A. Roe, Francis S. Collins, Stephen J. Marx, Lee Burns, Settara C. Chandrasekharappa

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations.

Original languageEnglish (US)
Pages (from-to)725-735
Number of pages11
JournalGenome Research
Volume7
Issue number7
StatePublished - Jul 1997
Externally publishedYes

Fingerprint

Multiple Endocrine Neoplasia Type 1
Genes
Neoplasms
Loss of Heterozygosity
Pituitary Neoplasms
Southern Blotting
Chromosomes
Mutation

ASJC Scopus subject areas

  • Genetics

Cite this

Guru, S. C., Agarwal, S. K., Manickam, P., Olufemi, S. E., Crabtree, J. S., Weisemann, J. M., ... Chandrasekharappa, S. C. (1997). A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Research, 7(7), 725-735.

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. / Guru, Siradanahalli C.; Agarwal, Sunita K.; Manickam, Pachiappan; Olufemi, Shodimu Emmanuel; Crabtree, Judy S.; Weisemann, Jane M.; Kester, Mary Beth; Kim, Young S.; Wang, Yingping; Emmert-Buck, Michael R.; Liotta, Lance A.; Spiegel, Allen M.; Boguski, Mark S.; Roe, Bruce A.; Collins, Francis S.; Marx, Stephen J.; Burns, Lee; Chandrasekharappa, Settara C.

In: Genome Research, Vol. 7, No. 7, 07.1997, p. 725-735.

Research output: Contribution to journalArticle

Guru, SC, Agarwal, SK, Manickam, P, Olufemi, SE, Crabtree, JS, Weisemann, JM, Kester, MB, Kim, YS, Wang, Y, Emmert-Buck, MR, Liotta, LA, Spiegel, AM, Boguski, MS, Roe, BA, Collins, FS, Marx, SJ, Burns, L & Chandrasekharappa, SC 1997, 'A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus', Genome Research, vol. 7, no. 7, pp. 725-735.
Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM et al. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Research. 1997 Jul;7(7):725-735.
Guru, Siradanahalli C. ; Agarwal, Sunita K. ; Manickam, Pachiappan ; Olufemi, Shodimu Emmanuel ; Crabtree, Judy S. ; Weisemann, Jane M. ; Kester, Mary Beth ; Kim, Young S. ; Wang, Yingping ; Emmert-Buck, Michael R. ; Liotta, Lance A. ; Spiegel, Allen M. ; Boguski, Mark S. ; Roe, Bruce A. ; Collins, Francis S. ; Marx, Stephen J. ; Burns, Lee ; Chandrasekharappa, Settara C. / A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. In: Genome Research. 1997 ; Vol. 7, No. 7. pp. 725-735.
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